Application of Highly Conserved Domain Sequences From Viral Genome As Template To Design Therapeutic Slirnas
AssigneeBiomics Biotechnologies Co., Ltd.
InventorsYork YuanYuan Zhu, Li Chen, TieJun Li, YiXiang Lu, YunCheng Sun, Jinkang Wang
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Abstract
This invention relates to the application of the highly conserved sequences of viral genome, especially from a highly conserved domain of enteroviral genome as templates to design target small ligand RNAs (sliRNAs). The resulting sliRNAs are therapeutically active ingredients in the treatment of the related diseases caused by pathological angiogenesis.
Claims20
An sliRNA for modulating a Toll-like Receptor (TLR), comprising a nucleotide sequence that is at least 90% identical to a fragment of a highly conserved domain of a viral genome sequence.
A method for designing a sliRNA, comprising:
- selecting a highly conserved domain of a viral genome sequence;
- and
- testing a RNA comprising a nucleotide sequence that is at least 90% identical to a fragment of said highly conserved domain for the ability of said RNA to modulate the activity of a Toll-like Receptor (TLR).
Dependencies are inferred from the claim text.