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US 2012/0071529 A1Published application
Tetrazole Compounds Which Selectively Modulate The CB2 Receptor
AssigneeBoehringer Ingelheim International GmbH
InventorsMonika ERMANN, Doris RIETHER, Renee M. ZINDELL
Life of this patent
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Abstract
Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
Claims11
A compound of the formula (I)
- wherein:
- R1 is C1-10 alkyl, C1-10 alkoxy, C3-10 cycloalkyl, 3-10 membered saturated heterocyclic ring or aryl each optionally independently substituted with 1-3 substituents chosen from C1-4 alkyl, C1-4 alkoxy, C3-10 cycloalkyl, C1-4 alkylsulfonyl, acyl, oxo, cyano, phenyl, hydroxyl and halogen;
- R2 and R3 are C1-4 alkyl or hydrogen with the proviso that both R2 and R3 cannot be hydrogen;
- or R2 and R3 together with the carbon atom to which they are attached form a 3- to 6-membered cycloalkyl or heterocyclic ring;
- R4 is hydrogen or methyl;
- R5 is chosen from C1-10 alkyl, C1-10 alkoxy, C3-10 cycloalkyl, 3-10 membered saturated heterocyclic ring, 5-6 membered heteroaryl ring and aryl each optionally independently substituted with 1-3 substituents chosen from C1-4 alkyl, C1-4 alkoxy, C3-10 cycloalkyl, C1-4 alkylsulfonyl, acyl, oxo, cyano, hydroxyl and halogen;
- n is 0, 1 or 2;
- wherein any carbon atom on the formula (I) or any R substituent listed above is optionally partially or fully halogenated where possible;
- or a pharmaceutically acceptable salt thereof.
6 more elements
A compound chosen from
- or a pharmaceutically acceptable salt thereof.
A compound chosen from:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.