Compounds for treatment of cancer
AssigneesGTx, Inc., University of Tennessee Research Foundation
InventorsYan Lu, Chien-Ming Li, Zhao Wang, Jianjun Chen, Wei Li, James T. DALTON, Duane D. Miller, Charles Duke, Sunjoo Ahn
Life of this patent
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Abstract
The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
Claims36
A compound represented by the structure of formula XI:
- wherein
- X is a bond, NH or S;
- Q is O, NH or S;
- and
- A is substituted or unsubstituted single-, fused- or multiple-ring, aryl or (hetero)cyclic ring systems;
- substituted or unsubstituted, saturated or unsaturated N-heterocycles;
- substituted or unsubstituted, saturated or unsaturated S-heterocycles;
- substituted or unsubstituted, saturated or unsaturated O-heterocycles;
- substituted or unsubstituted, saturated or unsaturated cyclic hydrocarbons;
- or substituted or unsubstituted or saturated or unsaturated mixed heterocycles;
- wherein said A ring is optionally substituted by 1-5 substituents which are independently O-alkyl, O-haloalkyl, F, Cl, Br, I, haloalkyl, CF3, CN, —CH2CN, NH2, hydroxyl, —(CH2)iNHCH3, —(CH2)iNH2, —(CH2)iN(CH3)2, —OC(O)CF3, C1-C5 linear or branched alkyl, haloalkyl, alkylamino, aminoalkyl, —OCH2Ph, —NHCO-alkyl, COON, —C(O)Ph, C(O)O-alkyl, C(O)H, —C(O)NH2 or NO2;
- and
- i is an integer between 0-5;
- wherein if Q is S, then X is not a bond.
The method according to 16, wherein said administering is carried out in combination with another cancer therapy.
A compound represented by the structure of formula XI(e):
- wherein R4 and R5 are independently hydrogen, O-alkyl, O-haloalkyl, F, Cl, Br, I, haloalkyl, CF3, CN, —CH2CN, NH2, hydroxyl, —(CH2)iNHCH3, —(CH2)iNH2, —(CH2)iN(CH3)2, —OC(O)CF3, C1-C5 linear or branched alkyl, haloalkyl, alkylamino, aminoalkyl, —OCH2Ph, —NHCO-alkyl, COON, —C(O)Ph, C(O)O-alkyl, C(O)H, —C(O)NH2 or NO2;
- i is an integer from 0-5;
- and
- n is an integer between 1-4.
The method according to 30, wherein said administering is carried out in combination with another cancer therapy.
Dependencies are inferred from the claim text.