Method and Composition for Treating Migraines
AssigneeMannKind Corporation
InventorsAndrea Leone-Bay, Grayson W. Stowell, Joseph J. Guarneri, Dawn M. Carlson, Marshall Grant, Chad C. Smutney
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Abstract
A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner.
Claims27
A method of treating symptoms associated with migraine comprising:
- administering to a subject in need of treatment for migraine symptoms a dry powder pharmaceutical composition comprising an effective amount of a serotonin receptor agonist and a diketopiperazine or a salt thereof.
A pharmaceutical composition comprising bis-3,6-[(N-fumaryl-4-aminobutyl)]-2,5-diketopiperazine or a salt thereof, and sumatriptan or rizatriptan.
A method of treating a migraine comprising:
- providing a patient with migraine symptoms a breath powered dry powder inhaler comprising a dry powder composition comprising bis-3,6[(N-fumaryl-4-aminobutyl)]-2,5-diketopiperazine, L-leucine and a triptan;
- and
- wherein a therapeutically effective amount of said dry powder composition is administered to said patient by oral inhalation.
Dependencies are inferred from the claim text.