Positive allosteric modulators of group ii mglurs

A compound of Formula I:

• or a pharmaceutically acceptable salt or solvate thereof, wherein:
• X and X′ are each independently absent or are each independently selected from O, S, and NR4;
• y is independently an integer selected from 0 and 1;
• q is independently an integer selected from 0, 1, 2, 3, 4, 5 and 6;
• m, n, and t are each independently an integer selected from 0, 1, 2, 3, and 4;
• T, U, V and W are each independently absent, or are each independently selected from C═O, CHR3, O, S, SO, SO2, and NR3, or T and U, U and V, or V and W each independently form —CR3═CR3′— or —CR3═N—, wherein T, U, V and W, together with the phenyl group to which T and W are attached, form a 5 or 6 membered ring;
• R1 and R2 are each independently selected from hydrogen, halogen, cyano, amino, nitro, hydroxyl, substituted or unsubstituted alkyl, perfluoroalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkylaryl, substituted or unsubstituted heteroalkylaryl, —(CH2)jOR5, —(CH2)jC(Z)R5, —(CH2)jC(O)OR5, —(CH2)jNR6R7, —(CH2)jC(O)NR6R7, —(CH2)jOC(O)NR6R7, —(CH2)jNR8C(O)R5, —(CH2)jNR8C(O)OR5, —(CH2)jNR8C(O)NR6R7, —(CH2)jS(O)kR9, —(CH2)jNR8S(O)2R9, and —(CH2)jS(O)2NR6R7;
• wherein each j is independently an integer selected from 0, 1, 2, 3, 4, 5 and 6;
• and each k is independently an integer selected from 0, 1 and 2;
• and Z is independently selected from O, S and Ne;
• R3 and R3′ are each independently selected from hydrogen, halogen, cyano, amino, nitro, hydroxyl, substituted or unsubstituted alkyl, perfluoroalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkylaryl, substituted or unsubstituted heteroalkylaryl;
• R4 is independently selected from hydrogen and substituted or unsubstituted alkyl;
• R5, R6, R7, R8, and R9 are each independently selected from hydrogen, halogen, cyano, amino, nitro, hydroxyl, substituted or unsubstituted alkyl, perfluoroalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkylaryl, substituted or unsubstituted heteroalkylaryl, or R5, R8, and R9 are as described above and R6 and R7, together with the nitrogen to which they are attached, form substituted or unsubstituted 3- to 7-membered heterocycloalkyl, or substituted or unsubstituted 5-membered heteroaryl;
• R is independently selected from hydrogen and substituted or unsubstituted alkyl;
• and
• wherein each of R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 is optionally independently substituted with 1 to 3 groups, each group independently selected from hydrogen, halogen, cyano, amino, aminomonoalkyl, aminodialkyl, nitro, hydroxyl, alkyl, perfluoroalkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heteroalkyl, heterocycloalkyl, aryl, heteroaryl, alkylaryl, and heteroalkylaryl.