Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates
AssigneeNektar Therapeutics
InventorsJennifer Riggs-Sauthier, Wen Zhang
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Abstract
The invention relates to (among other things) oligomer-PTK inhibitor conjugates and related compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over PTK inhibitor compounds lacking a water soluble, non peptidic oligomer.
Claims21
A compound comprising a protein tyrosine kinase inhibitor residue covalently attached via a stable or degradable linkage to a water-soluble, non-peptidic oligomer.
A method of making a protein tyrosine kinase inhibitor conjugate, the method comprising covalently attaching a water-soluble, non-peptidic oligomer to a protein tyrosine kinase inhibitor.
A method comprising administering to a mammal a compound comprising a protein tyrosine kinase inhibitor residue covalently attached via a stable or degradable linkage to a water-soluble, non-peptidic oligomer.
Dependencies are inferred from the claim text.