Derivatives of n-acyl-n'-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes
AssigneeTakeda Pharmaceutical Company Limited
InventorsShizuo Kasai, Kevin Francis McGee, JR.
Life of this patent
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Abstract
The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, which has a superior RBP4-lowering action and is useful as a pharmaceutical composition for the prophylaxis or treatment of a disease or condition mediated by an increase in RBP4.
Claims19
A compound represented by the formula
- wherein
- ring A is a benzene ring optionally further substituted;
- ring B is a piperazine ring optionally further substituted;
- and
- R is a substituent,
- with the proviso that tert-butyl 4-[2-tert-butyl-5-({[2-(1H-indazol-6-ylamino)pyridin-3-yl]carbonyl}amino)phenyl]piperazine-1-carboxylate is excluded,
- or a salt thereof.
N-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}glycine or a salt thereof.
3-[4-(2-tert-Butylphenyl)piperazin-1-yl]-3-oxopropanoic acid or a salt thereof.
[4-(2-tert-Butyl-4-chlorophenyl)piperazin-1-yl](oxo)acetic acid or a salt thereof.
A retinol binding protein 4-lowering agent comprising a compound represented by the formula
- wherein
- ring A is a benzene ring optionally further substituted;
- ring B is a piperazine ring optionally further substituted;
- and
- R is a substituent,
- or a salt thereof or a prodrug thereof.
An agent for the prophylaxis or treatment of diabetes, comprising a compound represented by the formula
- wherein
- ring A is a benzene ring optionally further substituted;
- ring B is a piperazine ring optionally further substituted;
- and
- R is a substituent,
- or a salt thereof or a prodrug thereof.
A method of lowering retinol binding protein 4 in a mammal, comprising administering an effective amount of a compound represented by the formula
- wherein
- ring A is a benzene ring optionally further substituted;
- ring B is a piperazine ring optionally further substituted;
- and
- R is a substituent,
- or a salt thereof or a prodrug thereof to the mammal.
A method for the prophylaxis or treatment of diabetes in a mammal, comprising administering an effective amount of a compound represented by the formula
- wherein
- ring A is a benzene ring optionally further substituted;
- ring B is a piperazine ring optionally further substituted;
- and
- R is a substituent,
- or a salt thereof or a prodrug thereof to the mammal.
Use of a compound represented by the formula
- wherein
- ring A is a benzene ring optionally further substituted;
- ring B is a piperazine ring optionally further substituted;
- and
- R is a substituent,
- or a salt thereof or a prodrug thereof, for manufacturing a retinol binding protein 4 lowering agent.
Use of a compound represented by the formula
- wherein
- ring A is a benzene ring optionally further substituted;
- ring B is a piperazine ring optionally further substituted;
- and
- R is a substituent,
- or a salt thereof or a prodrug thereof, for manufacturing a pharmaceutical composition for the prophylaxis or treatment of diabetes.
Dependencies are inferred from the claim text.