Therapeutic approaches for treating alzheimer disease and related disorders through a modulation of cell stress response
AssigneePharnext
InventorsDaniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Oxana Guerassimenko
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Abstract
The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate cell stress response for treating said disease.
Claims13
A composition comprising sulfisoxazole, or a salt, prodrug, derivative, or sustained release formulation thereof, for treating Alzheimer's disease (AD) in a subject in need thereof.
A composition comprising at least one of the following drug combinations, or salts or prodrugs or derivatives or sustained release formulations thereof, the drugs in each of said combinations being for simultaneous, separate or sequential administration:
- sulfisoxazole and zonisamide,
- sulfisoxazole and terbinafine, or
- sulfisoxazole and levosimendan.
A composition comprising at least tadalafil, or a salt, prodrug, derivative, or sustained release formulation thereof, for treating Alzheimer's disease (AD) in a subject in need thereof.
A method of producing a drug for treating Alzheimer's disease, the method comprising a step of testing a candidate drug for activity on cell stress response and selecting drugs which inhibit cell stress response.
A method of treating Alzheimer's disease, the method comprising administering to a subject in need thereof, an effective amount of sulfisoxazole, or a salt, prodrug, derivative, or sustained release formulation thereof.
Dependencies are inferred from the claim text.