Substituted benzotriazines and quinoxalines as inhibitors of p7os6 kinase

A compound of the formula (1):

• or a salt or tautomer thereof;
• wherein:
• X1 is N or N+(O−);
• X2 is N or CH;
• Q is a C1-3 alkylene group;
• R1 is selected from hydrogen, C1-4 hydrocarbyl and hydroxy-C2-4 hydrocarbyl;
• R2, R3 and R4 are the same or different and each is selected from hydrogen, fluorine, chlorine and methyl;
• Ar1 is a monocyclic 5 or 6-membered aryl or heteroaryl ring containing 0, 1 or 2 heteroatom ring members selected from O, N and S, or a naphthyl ring, the aryl or heteroaryl or naphthyl ring being optionally substituted with 1, 2 or 3 substituents selected from fluorine;
• chlorine;
• bromine;
• C1-4 hydrocarbyl;
• C1-4 hydrocarbyloxy;
• trifluoromethyl;
• difluoromethyl;
• hydroxy;
• cyano;
• trifluoromethoxy;
• difluoromethoxy;
• amino;
• mono-C1-4 hydrocarbylamino;
• di-C1-4 hydrocarbylamino;
• C1-4 hydrocarbyl-C(O)—;
• C1-4 hydrocarbyl-C(O)-amino;
• C1-4 hydrocarbylsulphonylamino;
• C1-4 hydrocarbylureido;
• sulphamoyl;
• mono-C1-4 hydrocarbylsulphamoyl;
• di-C1-4 hydrocarbylsulphamoyl;
• carbamoyl;
• mono-C1-4 hydrocarbyl carbamoyl;
• di-C1-4 hydrocarbyl carbamoyl;
• a group O—(CH2)k—OR5;
• and a group Om—(CH2)n—NR6R7;
• k is 2 to 4;
• m is 0 or 1 and n is 0, 1, 2, 3 or 4 provided that when m is 1 then n is at least 2;
• R5 is hydrogen or C1-4 hydrocarbyl;
• R6 is hydrogen or C1-4 hydrocarbyl;
• R7 is hydrogen or C1-4 hydrocarbyl;
• or NR6R7 forms a saturated five or six membered heterocyclic ring optionally containing a further heteroatom selected from O, N and S or oxidised forms thereof, the heterocyclic ring being optionally substituted with 1 to 4 C1-4 hydrocarbyl groups or hydroxy;
• Ar2 is a monocyclic 5 or 6-membered heteroaryl ring containing 1, 2 or 3 heteroatom ring members selected from O, N and S and being optionally substituted with 1, 2 or 3 substituents selected from fluorine;
• chlorine;
• bromine;
• C1-4 hydrocarbyl;
• C1-4 alkoxy;
• trifluoromethyl;
• difluoromethyl;
• hydroxy;
• cyano;
• trifluoromethoxy;
• difluoromethoxy;
• amino;
• mono-C1-4 hydrocarbylamino;
• di-C1-4 hydrocarbylamino;
• C1-4 hydrocarbyl-C(O)—;
• C1-4 hydrocarbyl-C(O)-amino;
• C1-4 hydrocarbylsulphonylamino;
• C1-4 hydrocarbylureido;
• sulphamoyl;
• mono-C1-4 hydrocarbylsulphamoyl;
• di-C1-4 hydrocarbylsulphamoyl;
• carbamoyl;
• mono-C1-4 hydrocarbyl carbamoyl;
• and di-C1-4 hydrocarbyl carbamoyl;
• and wherein, in each substituent consisting of or containing C1-4 hydrocarbyl, the C1-4 hydrocarbyl is selected from C1-4 alkyl, C2-4 alkenyl, alkynyl, cyclopropyl and cyclopropylmethyl.