Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders

A compound according to formula I, or a stereoisomer, tautomer, salt, hydrate or prodrug thereof:

• wherein:
• each W1 through W4 is independently a carbon atom or a nitrogen atom, wherein one of W1-W4 is nitrogen, and W5 and W6 are carbon, with the proviso that when any W1 through W4 is N, then the corresponding substituent(s) X1 through X4 is (are) absent;
• each X1 through X3 is independently selected from hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy, haloalkyl, trifluoromethyl, nitro, cyano, primary, secondary or tertiary amino;
• each X5 and X6 is independently selected from hydrogen and lower alkyl;
• X4 is selected from hydrogen, halogen, or is selected from the following groups:
• wherein:
• m is an integer from 1 to 4, and n is an integer from 0 to 4;
• R2 is selected from optionally substituted aryl, heteroaryl wherein said heteroaryl is imidazoyl, pyridinyl benzo-dioxanyl, benzo-dioxolyl, benzo-imidazolyl or indolyl, or —(CH2)p-M1-aryl, substituted by substituents independently selected from a group consisting of hydrogen, lower alkoxy, aryloxy, benzyloxy, alkylthio hydroxy, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, lower alkyl, lower alkenyl, methylenedioxy, trimethylene, cyano, nitro, tertiary amino, such as dimethylamino, carboxamide, lower alkylsulfonyl, lower alkylthio, optionally substituted aryl or heteroaryl, wherein M1 is O or S, and p is an integer between 0 and 4;
• R3 is selected from optionally substituted aryl, heteroaryl, wherein the heteroaryl is imidazoyl, pyridinyl benzo-dioxanyl, benzo-imidazolyl or indolyl, —(CH2)o-aryl, or —(CH2)o-heteroaryl wherein o is an integer from 0 to 5, substituted by a substituent independently selected from a group consisting of hydrogen, lower alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, lower alkyl, cyano, nitro, primary, secondary or tertiary amino, carboxamide, optionally substituted aryl or heteroaryl;
• Y1 is independently selected from:
• wherein:
• q is an integer from 0 to 4;
• R#10 is selected from hydrogen, lower alkyl, hydroxy and lower alkoxy;
• each (CH2)q can be optionally substituted with one or more groups selected from hydrogen, lower alkyl, heteroalkyl, heterocyclo, hydroxy-lower alkyl, cycloalkyl and hydroxycycloalkyl, wherein such substituents can be joined to form a cyclic structure and wherein one or more of the methylene groups of (CH2)q can be replaced by a carbonyl group (C═O);
• Y2 is independently selected from:
• wherein:
• r is an integer from 0 to 4;
• R#11 is selected from hydrogen, lower alkyl, hydroxy and lower alkoxy;
• each (CH2)r can be optionally substituted with one or more groups selected from hydrogen, lower alkyl, heteroalkyl, heterocyclo, hydroxy-lower alkyl, cycloalkyl, hydroxycycloalkyl, wherein such substituents can be joined to form a cyclic structure, and wherein one or more of the methylene groups of (CH2)r can be replaced by a carbonyl group (C═O);
• and
• R1 is independently selected from optionally substituted nitrogen containing heterocyclyl;
• nitrogen containing heterocyclylalkyl;
• wherein said heterocyclyl and heterocyclylalkyl are piperidinyl, pyrrolidinyl, piperazinyl, azetidinyl, morpholinyl, or quinucleodinyl;
• and nitrogen containing heteroarylalkyl, wherein substitutions are selected from:
• hydrogen, lower alkyl, hydroxy, lower alkoxy, amino, di-(lower alkyl)aminoalkyl carboxamido, sulfonamido, SO2-alkyl, SO-alkyl, CO-alkyl, CO2-alkyl, cyano, cyanoalkyl, ketoalkyl, and methanesulfonylalkyl.