Back to results
US 2012/0071471 A1Published application
Novel benzoxazinone derivatives useful for the treatment of cns disorders
AssigneeNeuroSearch A/S
InventorsAntonio Nardi, Karin de Linde Troelsen, Helle Kirstein Erichsen
Life of this patent
Estimating the term…
Abstract
The present invention encompasses novel 1,4-dihydro-3,1-benzoxazin-2-one derivatives, which are surprisingly found to be efficacious in animal models of CNS disorders and, as such, are valuable candidates for the prevention or treatment of CNS (Central Nervous System) diseases or disorders.
Claims10
A benzoxazinone derivative represented by Formula I
- a stereoisomer thereof or a mixture of its stereoisomers, or a pharmaceutically acceptable salt thereof, wherein
- at least one of R1, R2, R3 and R4, independently of each other, represents halo or cyano;
- and
- the other of R1, R2, R3 and R4, independently of each other, represent hydrogen, halo or cyano;
- R5 represents hydrogen or alkyl;
- R6 and R7, independently of each other, represent hydrogen or alkyl;
- and
- X represents an imidazole group, a 4,5-dihydro-1H-imidazole group, or the group —(CO)N(R6, R7), wherein R6 and R7, independently of each other, represent hydrogen or alkyl.
5 more elements
8-10. (canceled)
Dependencies are inferred from the claim text.