Hydroxy and alkoxy substituted 1h-imidazoquinolines and methods

A compound of the Formula I:

• wherein:
• R2 is selected from the group consisting of hydrogen, C1-4 alkyl, hydroxyC2-4 alkylenyl, and C1-4 alkoxyC2-4 alkylenyl;
• R1 is selected from the group consisting of:
• hydrogen,
• —CH(R11)—Ar,
• —CH(R11)—Ar′—R4,
• —CH(R11)—Ar′—Y—R4,
• —CH(R11)—Ar′—CH(R11)—Y—R4,
• —CH(R11)—Ar′—R5,
• —CH(R11)—Ar′—CH(R11)—R5,
• —X1-Het, and
• —X1—N(R8)-Q-R4;
• Ar is selected from the group consisting of aryl and heteroaryl each of which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkenyl, alkoxy, methylenedioxy, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, hydroxyalkyl, cyano, amino, alkylamino, and dialkylamino;
• Ar′ is selected from the group consisting of arylene and heteroarylene each of which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkenyl, alkoxy, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, hydroxyalkyl, cyano, amino, alkylamino, and dialkylamino;
• Het is heterocyclyl which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, hydroxyalkyl, cyano, hydroxyalkyleneoxyalkylenyl, amino, alkylamino, dialkylamino, and oxo;
• X1 is C1-6 alkylene that is optionally interrupted by one or more —O— groups;
• R11 is selected from the group consisting of hydrogen and C1-3 alkylene;
• Y is selected from the group consisting of:
• —O—,
• —S(O)0-2—,
• —S(O)2—N(R8)—,
• —C(R6)—,
• —C(R6)—O—,
• —O—C(R6)—,
• —O—C(O)—O—,
• —N(R8)-Q-,
• —C(R6)—N(R8)—,
• —O—C(R6)—N(R8)—,
• —C(R6)—N(OR9)—,
• —O—N(R8)-Q-,
• —O—N═C(R4)—,
• —C(═N—O—R8)—,
• —CH(—N(—O—R8)-Q-R4)—,
• R4 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl wherein the alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl groups can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl;
• alkoxy;
• hydroxyalkyl;
• haloalkyl;
• haloalkoxy;
• halogen;
• nitro;
• hydroxy;
• mercapto;
• cyano;
• aryl;
• aryloxy;
• arylalkyleneoxy;
• heteroaryl;
• heteroaryloxy;
• heteroarylalkyleneoxy;
• heterocyclyl;
• amino;
• alkylamino;
• dialkylamino;
• (dialkylamino)alkyleneoxy;
• and, in the case of alkyl, alkenyl, alkynyl, and heterocyclyl, oxo;
• R5 is selected from the group consisting of:
• R6 is selected from the group consisting of ═O and ═S;
• R7 is C2-7 alkylene;
• R8 is selected from the group consisting of hydrogen, C1-10 alkyl, C2-10 alkenyl, hydroxy-C1-10 alkylenyl, C1-10 alkoxy-C1-10 alkylenyl, aryl-C1-10 alkylenyl, and heteroaryl-C1-10 alkylenyl;
• R9 is selected from the group consisting of hydrogen and alkyl;
• R10 is C3-8 alkylene;
• A is selected from the group consisting of —CH2—, —O—, —C(O)—, —S(O)0-2—, and —N(-Q-R4)—;
• A′ is selected from the group consisting of —O—, —S(O)0-2—, —N(-Q-R4—, and —CH2—;
• Q is selected from the group consisting of a bond, —C(R6)—, —C(R6)—C(R6)—, —S(O)2—, —C(R6)—N(R8)—W—, —S(O)2—N(R8)—, —C(R6)—O—, —C(R6)—S—, and —C(R6)—N(OR9)—;
• V is selected from the group consisting of —C(R6)—, —O—C(R6)—, —N(R8)—C(R6)—, and —S(O)2—;
• W is selected from the group consisting of a bond, —C(O)—, and —S(O)2—;
• and
• a and b are independently integers from 1 to 6 with the proviso that a+b is ≦7;
• or a pharmaceutically acceptable salt thereof.