Substituted Benzamide Compounds

A compound corresponding to formula (I):

• wherein
• a represents 0 or 1;
• t represents 1, 2 or 3;
• b represents 0, 1 or 2;
• c and d each independently represent 0, 1 or 2, with the proviso that c+d is less than or equal to 3;
• X represents N(R9a) or C(R9b)(H);
• D represents
• q represents 0 or 1;
• s represents 0 or 1;
• r represents 1, 2 or 3;
• B represents C(═O), S(═O)2 or the group C(═O)—N(R10), wherein the nitrogen atom thereof is bonded to the radical R1;
• Q1 and Q2 each independently represent C, CH or N;
• R1 represents C1-9-alkyl, aryl, heteroaryl, CH(aryl)2, C3-8-cycloalkyl, heterocyclyl, or aryl, heteroaryl, CH(aryl)2, C3-8-cycloalkyl or heterocyclyl bonded via a C1-6-alkylene group, C2-6-alkenylene group or C2-5-alkynylene group;
• R2 represents H, C1-6-alkyl, C3-8-cycloalkyl, heterocyclyl, aryl, heteroaryl, or C3-8-cycloalkyl, heterocyclyl, aryl or heteroaryl bonded via a C1-6-alkylene group;
• R3 and R4, together with the group -Q1-Q2- linking them, form a ring which is unsubstituted or substituted on one or more of its carbon ring members by one or more substituents independently selected from the group consisting of F, Cl, Br, I, CF3, C1-6-alkyl, alkyl, OH, OCF3, SH, SCF3, aryl and heteroaryl and/or can be fused with at least one aryl or heteroaryl, wherein the ring is saturated, mono- or poly-unsaturated or aromatic, is 4-, 5-, 6- or 7-membered and can optionally contain one or more heteroatoms or heteroatom groups independently selected from the group consisting of N, NR11, O, S, S(═O) and S(═O)2;
• wherein
• R11 denotes H, C(═O)—R12, C3-8-cycloalkyl, aryl, heteroaryl, or C3-8-cycloalkyl, aryl or heteroaryl bonded via a C1-3-alkylene group, and
• R12 denotes C1-6-alkyl, C3-8-cycloalkyl, aryl, heteroaryl, or C3-8-cycloalkyl, aryl or heteroaryl bonded via a C1-3-alkylene group;
• R5 represents 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of F, Cl, CF3, OCF3, C1-6-alkyl and O—C1-6-alkyl, and/or two adjacent substituents R5form a fused aryl, heteroaryl or C4-8-cycloalkyl, and/or two substituents R5 bonded to a carbon atom form a 3-, 4- or 5-membered, saturated carbocyclic ring which is unsubstituted or substituted on one or more of its carbon ring members by one or more substituents independently selected from the group consisting of F, CF3 and C1-6-alkyl;
• R6 represents 0, 1, 2 or 3 substituents independently selected from the group consisting of F, Cl, Br, CF3, OCF3, OH, C1-6-alkyl, C3-8-cycloalkyl, NO2, NH2, N(H)(C1-6-alkyl) and N(C1-6-alkyl)2, and/or two adjacent substituents R6 form a fused aryl, heteroaryl or C4-8-cycloalkyl;
• R7 represents H, C3-8-cycloalkyl, heterocyclyl, aryl or heteroaryl, or denotes C3-8-cycloalkyl, heterocyclyl, aryl or heteroaryl bonded via a C1-6-alkylene group;
• R8 represents 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of CF3, C1-6-alkyl, C3-8-cycloalkyl and aryl, and/or two substituents R8 bonded to a carbon atom form a C(═O) group or a 3-, 4-, 5- or 6-membered, saturated carbocyclic ring which is unsubstituted or substituted on one or more of its carbon ring members by one or more substituents independently selected from the group consisting of F, CF3 and C1-6-alkyl;
• R9a represents C(═O)—R13, S(═O)2—R13, C(═O)—N(R14)—R13, CHR15R16, C3-8-cycloalkyl, heterocyclyl, aryl or heteroaryl, or represents CHR15R16, C3-8-cycloalkyl, heterocyclyl, aryl or heteroaryl bonded via a C1-6-alkylene group;
• R9b represents NR17R18, C1-6-alkylene-NR17R18, O—C1-6-alkylene-NR17R18, C(═O)—NR17R18, OR19, C1-6-alkylene-OR19, C1-6-alkylene-O—C1-6-alkylene-OR19, C1-6-alkyl, C3-8-cycloalkyl, heterocyclyl, aryl, heteroaryl, or C3-8-cycloalkyl, heterocyclyl, aryl or heteroaryl bonded via a C1-6-alkylene group;
• R10 represents H, C1-6-alkyl, C3-8-cycloalkyl, heterocyclyl, aryl, heteroaryl, or C3-8-cycloalkyl, heterocyclyl, aryl or heteroaryl bonded via a C1-3-alkylene group;
• R13 represents C1-6-alkyl, aryl, heteroaryl, CH(aryl)2, C3-8-cycloalkyl, heterocyclyl, or aryl, heteroaryl, C3-8-cycloalkyl or heterocyclyl bonded via a C1-6-alkylene group, C2-6-alkenylene group or C2-6-alkynylene group;
• R14 represents H, C1-6-alkyl, C3-8-cycloalkyl, aryl, heteroaryl, or C3-8-cycloalkyl, aryl or heteroaryl bonded via a C1-3-alkylene group;
• R15 and R16 each independently represent H, C1-4-alkyl, C3-8-cycloalkyl, aryl or heteroaryl, or
• R15 and R16, together with the CH grouping linking them, form a 4-, 5-, 6- or 7-membered ring which is unsubstituted or substituted on one or more of its carbon ring members by one or more substituents independently selected from the group consisting of F, Cl, Br, I, CF3, C1-6-alkyl, O—C1-6-alkyl, OH, OCF3, SH, SCF3, NR20R21, aryl and heteroaryl, wherein said ring may be saturated or mono- or poly-unsaturated but not aromatic, and can optionally contain one or more heteroatoms or heteroatom groups independently selected from the group consisting of N, NR24, O, S, S(═O) and S(═O)2;
• wherein
• R24 denotes H, C1-6-alkyl, C(═O)—R25, C3-8-cycloalkyl, aryl, heteroaryl, or C3-8-cycloalkyl, aryl or heteroaryl bonded via a C1-3-alkylene group, and
• R25 denotes C1-6-alkyl, C3-8-cycloalkyl, aryl, heteroaryl, or C3-8-cycloalkyl, aryl or heteroaryl bonded via a C1-3-alkylene group;
• R17 and R18 each independently represent H, C1-6-alkyl or C3-8-cycloalkyl, or
• R17 and R18, together with the nitrogen atom linking them, form a 4-, 5-, 6- or 7-membered heterocyclic ring which is unsubstituted or substituted on one or more of its carbon ring members by one or more substituents independently selected from the group consisting of F, Cl, Br, I, CF3, C1-6-alkyl, O—C1-6-alkyl, OH, OCF3, SH, SCF3, NR20R21, aryl and heteroaryl and/or can be fused with at least one aryl or heteroaryl, wherein the heterocyclic ring is saturated or mono- or poly-unsaturated, and can optionally contain 1, 2 or 3 heteroatoms or heteroatom groups independently selected from the group consisting of N, NR22, O, S, S(═O) and S(═O)2;
• wherein
• R22 denotes H, C1-6-alkyl, —C(═O)—R23, C3-8-cycloalkyl, aryl, heteroaryl, or C3-8-cycloalkyl, aryl or heteroaryl bonded via a C1-3-alkylene group, and
• R23 denotes C1-6-alkyl, C3-8-cycloalkyl, aryl, heteroaryl, or C3-8-cycloalkyl, aryl or heteroaryl bonded via a C1-3-alkylene group;
• R19 represents H, C1-6-alkyl, C3-8-cycloalkyl, heterocyclyl, aryl, heteroaryl or C2-6-alkylene-NR17R18, or heterocyclyl, C3-8-cycloalkyl, aryl or heteroaryl bonded via a C1-6-alkylene group;
• R20 and R21 each independently represent H, C1-6-alkyl or C3-8-cycloalkyl, or
• R20 and R21, together with the nitrogen atom linking them, form a 4-, 5-, 6- or 7-membered heterocyclic ring which is unsubstituted or substituted on one or more of its carbon ring members by one or more substituents independently selected from the group consisting of F, Cl, Br, I, CF3, C1-6-alkyl, O—C1-6-alkyl, OH, OCF3, SH, SCF3, aryl and heteroaryl, wherein the heterocyclic ring may be saturated or mono- or poly-unsaturated but not aromatic, and can optionally contain one or more heteroatoms or heteroatom groups independently selected from the group consisting of N, NR26, O, S, S(═O) and S(═O)2;
• wherein
• R26 denotes H, C1-6-alkyl, C(═O)—R27, C3-8-cycloalkyl, aryl, heteroaryl, or C3-8-cycloalkyl, aryl or heteroaryl bonded via a C1-3-alkylene group, and
• R27 denotes C1-6-alkyl, C3-8-cycloalkyl, aryl, heteroaryl, or C3-8-cycloalkyl, aryl or heteroaryl bonded via a C1-3-alkylene group;
• wherein
• the above-mentioned C1-4-alkyl, C1-6-alkyl, C1-3-alkylene, C1-6-alkylene, C2-6-alkylene, C2-6-alkenylene, C2-6-alkynylene, C3-8-cycloalkyl, C4-8-cycloalkyl, heterocyclyl, aryl and heteroaryl groups can each be unsubstituted or substituted one or more times by identical or different substituents, and
• the above-mentioned C1-4-alkyl, C1-6-alkyl, C1-3-alkylene, C1-6-alkylene, C2-6-alkylene, C2-6-alkenylene and C2-6-alkynylene groups can each be branched or unbranched;
• or an N-oxide or physiologically acceptable salt thereof.