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US 2012/0071458 A1Published application
Methods for treating obesity
OwnerGerald L. Wislerinventor
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Abstract
The invention is directed to methods for treating and/or controlling obesity in a patient. The methods involve combination therapies using a microsomal triglyceride transfer protein (MTP) inhibitor (for example, AEGR-733 and implitapide) and a cholesterol absorption inhibitor (CAI) (for example, ezetimibe).
Claims21
A method of treating and/or controlling obesity comprising administering to a patient in need thereof a daily dosage between about 5 to about 12 mg/day inclusive for at least twelve weeks, of an MTP inhibitor represented by:
- in combination with a daily dose of 10 mg of ezetimibe, wherein after the twelve weeks, the reduction in body mass of the patient is greater that the additive effect of 12 weeks of daily administration of ezetimibe or the MTP inhibitor alone.
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Dependencies are inferred from the claim text.