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US 2012/0071451 A1Published application
Method of treating nonalcoholic steatohepatitis with elevated doses of ursodeoxycholic acid
AssigneeAptalis Pharma Canada Inc.
InventorsJean SPENARD, Vlad RATZIU, Marc RIVIERE
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Abstract
The present invention is directed to a method for the treatment of nonalcoholic steatohepatitis (NASH) by administering an elevated dose of ursodeoxycholic acid (UDCA), or a pharmaceutically acceptable salt thereof, to a patient in need of such treatment, wherein the patients demonstrate a significantly improved glycemic profile during treatment.
Claims20
A method for treating nonalcoholic steatohepatitis (NASH), comprising administering a dose of about 28-35 mg ursodeoxycholic acid (UDCA), or a pharmaceutically acceptable salt thereof, per kg body weight per day to a patient in need thereof,
- wherein the method reduces fibrosis levels and/or liver inflammation levels in the patient compared to pre-treatment levels.
Dependencies are inferred from the claim text.