Tunable crosslinked polysaccharide compositions
AssigneeAllergan, Inc.
InventorsDimitrios Stroumpoulis, Ahmet Tezel
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Abstract
The present specification generally relates to injectable dermal fillers including multifunctional polyethylene glycol-based crosslinking agents, hydrogel compositions comprising a matrix polymer crosslinked with such crosslinking agents, and methods of treating a soft tissue condition using such hydrogel compositions.
Claims19
An injectable hydrogel composition comprising:
- a crosslinked hyaluronan polymer, wherein the hyaluronan polymer is crosslinked with pentaerythritol tetraglycidyl ether (PEGE) and the composition has a PEGE/hyaluranon polymer concentration of about 10% to about 15% (w/w).
A method of making an injectable hydrogel composition comprising the steps of hydrating dry sodium hyaluronate (NaHA);
- adding PEGE to crosslink the hydrated NaHA to obtain a NaHA/PEGE mixture having a PEGE/NaHA concentration of about 10% to about 15% (w/w);
- neutralizing and swelling the NaHA/PEGE mixture;
- dialyzing the NaHA/PEGE mixture to reach a NaHA concentration of about 18 mg/mL to about 28 mg/mL.
An injectable hydrogel composition comprising sodium hyaluronate (NaHA) crosslinked with pentaerythritol tetraglycidyl ether (PEGE),
- wherein the NaHA has a mean molecular weight of between about 310,000 Da and about 840,000 Da, and
- wherein the NaHA is present in the composition at a concentration of about 18 mg/mL to about 28 mg/mL.
An injectable dermal filler composition for treating wrinkles in facial skin, the composition comprising a crosslinked hyaluronan polymer, wherein the hyaluronan polymer is crosslinked with pentaerythritol tetraglycidyl ether (PEGE) and the composition has a PEGE/hyaluranon polymer concentration of about 10% to about 15% (w/w).
Dependencies are inferred from the claim text.