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US 2012/0071433 A1Published application
Substituted 6-(Benzylamino) Purine Riboside Derivatives, Use Thereof and Compositions Containing These Derivatives
OwnerLucie Szucova, Viadimir Krystof +4inventors
InventorsLucie Szucova, Viadimir Krystof, Marek Zatloukal, Karel Dolezal, Miroslav Strnad, Lukas Spichal
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Abstract
The invention relates to 2-substituted-6-(substituted benzylamino)purine riboside derivatives of the general formula I. These compounds possess antiapoptotic, anti-inflammatory and differentiating activities. The invention relates also to the compositions, which contain these derivatives as active ingredients.
Claims9
2-Substituted-6-(substituted benzylamino)purine riboside derivatives of the general formula I
- wherein
- (R)n represents 0 to 4 substituents (n is 0-4), which can be the same or different, the substituents being selected from the group comprising alkyl, alkoxy, amino, halogen, hydroxyl, nitro, mercapto and alkylmercapto, and
- R1 is selected from the group consisting of halogen, hydroxy, amino, alkoxy, mercapto, alkylmercapto, alkyl, and
- R2 is selected from the group consisting of halogen, amino, azido, hydroxy, alkoxy, mercapto, alkylmercapto, alkyl, alkenyl, alkynyl, —NHNH2, —NHOH, —NHCONH2, guanylo (—NH—C(NH)NH2), and
- R2 is R2′-N(R3)- wherein
- R2′ is selected from the group consisting of alkyl, alkenyl, cycloalkyl, phenyl and benzyl, wherein each of the groups can optionally be substituted by one or more substituents selected from the group comprising amino, halogen, hydroxy, alkoxy, mercapto and alkylmercapto,
- R3 is selected from hydrogen and alkyl, said alkyl being unsubstituted or substituted by one or more substituents selected from the group comprising amino, halogen, hydroxy, alkoxy, mercapto and alkylmercapto,
- and the pharmaceutically acceptable salts thereof with alkali metals, ammonium or amines, or their addition salts with acids.
5 more elements
Dependencies are inferred from the claim text.