Heterotricyclic AMPA Receptor Antagonists for Treatment of Epilepsy, Pain, and Other Neurological Disorders and Diseases
AssigneeNorthwestern University
InventorsGeoffrey T. Swanson, Martin B. Gill, Ryuichi Sakai, Masato Oikawa
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Abstract
Disclosed are heterotricyclic compounds, pharmaceutical compositions, methods of treatment, and methods for selectively antagonizing a glutamate receptor. The pharmaceutical compositions may include and the methods may utilize heterotricyclic compounds that are glutamate analogues which have specificity for AMPA receptors. The pharmaceutical compositions may be utilized to treat or prevent neurological diseases or disorders.
Claims20
A pharmaceutical composition comprising:
- (a) a compound having a formula:
- or a salt, ester, amide, or solvate thereof, wherein
- X is —NH— or —O—;
- Y is C3-C4-alkanediyl or C3-C4-alkenediyl, optionally substituted at one or more carbon positions with —OH;
- and
- Z is —CH1— or —CO—, and
- (b) one or more pharmaceutically acceptable carriers, diluents, or excipients.
A method for selectively antagonizing a glutamate receptor, the method comprising contacting the receptor with a compound having a formula:
- or a salt, ester, amide, or solvate thereof, wherein
- X is —NH— or —O—;
- Y is C3-C4-alkanediyl or C3-C4-alkenediyl that is optionally substituted at one or more carbon positions with —OH;
- and Z is —CH2— or —CO—.
Dependencies are inferred from the claim text.