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AssigneeAbbott Laboratories
InventorsTracey Colpitts, Eric L. Russell, Stephen Frost, Javier Ramirez, Bhawani Singh, John C. Russell
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The present invention relates to rapid, sensitive methods for determining whether a subject has or is at risk of developing lung cancer based on certain combinations of biomarkers, or biomarkers and biometric parameters. The methods consist of: a) quantifying in a test sample obtained from a subject, the amount of two or more biomarkers in a panel, the panel comprising at least one antibody and at least one antigen: b) comparing the amount of each biomarker quantified in the panel to a predetermined cutoff for said biomarker and assigning a score for each biomarker based on said comparison: c) combining the assigned score for each biomarker quantified in step b to obtain a total score for said subject: d) comparing the total score in step c with a predetermined total score and e) determining whether said subject has a risk of lung cancer based on the comparison in step d.
A method of aiding in a diagnosis of a subject suspected of lung cancer, the method comprising the steps of:
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A kit comprising:
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A kit comprising:
An isolated polypeptide having an amino acid sequence selected from the group consisting of:
An isolated polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:4 and a polypeptide having 60% homology to the amino acid sequence of SEQ ID NO:4.
An isolated polypeptide having an amino acid sequence selected from the group consisting of:
Dependencies are inferred from the claim text.