Amino Acid Sequences which Enhance Peptide Conjugate Solubility
AssigneeThe United States Government as represented by the Department of Veterans Affairs
InventorRichard H. Weisbart
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Abstract
The present invention provides peptide conjugates having improved solubility as well as increased secretion during cell based production, as well as methods of utilizing such peptides. The peptide conjugates include a short peptide domain defined by the amino acid sequence AGIH (SEQ ID NO: 8) and may include a biologically active molecule useful in intracellular and intranuclear transport of the biologically active molecule to treat various disorders and diseases.
Claims22
A peptide-antibody conjugate comprising,
- a peptide of about 4 to 50 amino acid residues comprising the amino acid sequence AGIH (SEQ ID NO:
- 8), and
- an antibody, variant thereof, or functional fragment thereof having a binding specificity of an antibody as produced by a hybridoma having ATCC accession number PTA 2439,
- wherein the peptide is conjugated to the N-terminus of the antibody, variant thereof, or functional fragment thereof.
An isolated peptide from about 4 to 50 amino acid residues comprising the amino acid sequence AGIH (SEQ ID NO:
- 8).
A peptide-biologically active molecule conjugate comprising,
- a peptide from about 4 to 50 amino acid residues comprising the amino acid sequence AGIH (SEQ ID NO:
- 8), and
- a biologically active molecule.
22-29. (canceled)
Dependencies are inferred from the claim text.