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AssigneeSenomyx, Inc.
InventorsGuy Servant, Hong Chang, Cyril Redcrow, Sumita Ray, Imran Clark, Bryan Moyer
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In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human taste tissue. The present invention further relates to amphibian oocyte-based medium-throughput electrophysiological assays for identifying human ENaC modulators, preferably ENaC enhancers. Compounds that modulate ENaC function in a cell-based ENaC assay are expected to affect salty taste in humans.
1-110. (canceled)
An isolated cell or cell population that expresses a functional hENaC comprising a delta subunit which is at least 95% identical to the polypeptide in SEQ ID NO:7 and an alpha and beta subunit which are respectively at least 95% identical to the polypeptides in SEQ ID NO:1 and 2.
Dependencies are inferred from the claim text.