Lateral flow microfluidic assaying device and related method
AssigneeCalifornia Institute of Technology
InventorsJun WANG, James R. HEATH
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Abstract
Provided herein is a microfluidic device and related method for controlling flow of different fluid components of a fluid. The microfluidic device comprises an input channel, focusing channel and an assaying channel. The microfluidic device is adapted to separate a fluid into at least two fluid components, and is further adapted to detect a target material comprised within one of the fluid components. The method comprises providing a channel, the channel having a dimension which is a function of a dimension of one of the fluid components and deliver the fluid through the channel at a set flow rate.
Claims22
A microfluidic device for controlling flow of a first fluid component and a second fluid component in a fluid sample, the first fluid component comprising at least one target, the device comprising:
- an inlet channel for introducing the fluid sample in the microfluidic device;
- a focusing channel in fluidic communication with the inlet channel;
- and
- an assaying channel in fluidic communication with the focusing channel, the assaying channel carrying at least one capture agent or component thereof, the at least one capture agent or component thereof attached to the assaying channel, the at least one capture agent having a binding affinity for the target,
- wherein
- the focusing channel is adapted to move the second fluidic component of the fluid sample in a distance away from surfaces of the assaying channel and keep the first fluid component in contact with the at least one capture agent or component thereof.
A method for separating a fluid into a first fluid component and a second fluid component, the second fluid component comprising particles within a certain size range, the method comprising:
- providing a channel, the channel having a dimension which is a function of the size range of the particles;
- and
- delivering the fluid through the channel at a set flow rate.
Dependencies are inferred from the claim text.