Determination of Interactions of Constant Parts of Antibodies with FC-Gamma Receptors
OwnerHartmut Hengel, Ulrich Kalinkeinventors
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Abstract
The invention relates to a novel method for the exact determination of the binding of the Fc-part of IgG-antibodies to Fc-gamma receptors, and for the simultaneous examination of the antigen-specificity and the Fc-gamma-receptor activation, as well as specific materials for use in said method. The invention furthermore relates to a method for identifying substances that affect the binding of the Fc-part of IgG-antibodies to Fc-gamma receptors, on the basis of the method for the exact determination of the binding of the Fc-part.
Claims19
A recombinant expression vector, comprising sequences for the recombinant expression of at least one fusion protein on the surface of a mammalian cell, wherein the fusion protein comprises a) an extracellular part of a mammalian Fc-receptor, b) a transmembrane region of a zeta-chain, and c) an intracellular signaling domain of a T-cell receptor zeta-chain.
Dependencies are inferred from the claim text.