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US 2012/0070512 A1Published application
Substituted 6-(2-hydroxybenzylamino)purine Derivatives, Their Use as Medicaments and Compositions Containing These Derivatives
AssigneesUniverzita Palackeho V Olomouci, Biopatterns, S.R.O.
InventorsMarek Zatloukal, Vladimir Krystof, Libor Havlicek, Igor Popa, Karel Dolezal, Miroslav Strnad, Radek Jorda
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Abstract
The invention relates to substituted 6-(2-hydroxybenzylamino)purines of general formula I, to their activity as cyclin-dependent kinases 2, 5, 7 and 9 inhibitors and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation or inflammation. The invention further includes pharmaceutical compositions containing the substituted 6-(2-hydroxybenzylamino)purines.
Claims12
Substituted 6-(2-hydroxybenzylamino)purines of the general formula I
- wherein
- (R)n represents 1 to 4 substituents, which can be the same or different, the substituents being selected from the group comprising alkyl, alkoxy, amino, halogen, hydroxy, mercapto and nitro, and
- R2 is R2′-NH— wherein
- R2′ is selected from the group consisting of alkyl, alkenyl, cycloalkyl, cycloalkyl alkyl, aryl and arylalkyl, wherein each of the groups can optionally be substituted by one or more substituents selected from the group comprising amino, hydroxy, mercapto, and alkoxy, and
- R9 is selected from the group consisting of alkyl, alkenyl, cycloalkyl, cycloalkyl alkyl, aryl and arylalkyl group,
- and the pharmaceutically acceptable salts thereof.
3 more elements
Dependencies are inferred from the claim text.