Nanoparticles Of Cerium Oxide Targeted To An Amyloid-Beta Antigen Of Alzheimer's Disease And Associated Methods
AssigneesUniversity of Central Florida Research Foundation, Inc., University of L'Aquila
InventorsAnnamaria Cimini, Barbara D'Angelo, Soumen Das, Sudipta Seal
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Abstract
Disclosed is a composition immunologically targeted to Alzheimer's disease (AD), the composition containing amine functionalized nanoparticles of Cerium oxide coated with polyethylene glycol and bearing an antibody specific for an amyloid-beta antigen associated with AD. The invention also includes a medication manufactured with the targeted nanoceria particles and methods of treatment by administering the targeted nanoceria particles to patients in need thereof.
Claims12
A composition comprising polyethylene glycol (PEG) coated nanoparticles of Cerium oxide having an antibody bound thereto, the antibody being specific for an antigen associated with a predetermined disease condition.
A composition specifically targeted to a neurodegenerative disease, said composition comprising amine functionalized nanoparticles of Cerium oxide coated with polyethylene glycol and bearing an antibody specific for an antigen associated with the neurodegenerative disease.
A composition immunologically targeted to Alzheimer's disease (AD), said composition comprising amine functionalized nanoparticles of Cerium oxide coated with polyethylene glycol and bearing an antibody specific for an amyloid-beta antigen associated with AD.
Dependencies are inferred from the claim text.