Submicron Particles of Antineoplastic Agents
AssigneesBaxter Healthcare S.A., Baxter International Inc.
InventorsMahesh V. Chaubal, Jane Werling, Barrett Rabinow
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Abstract
The present invention is concerned with the formation of submicron particles of an antineoplastic agent, particularly paclitaxel, by precipitating the antineoplastic agent in an aqueous medium to form a pre-suspension followed by homogenization. Surfactants with phospholipids conjugated with a water soluble or hydrophilic polymer such as PEG are used as coating for the particles. The particles produced generally have an average particle size of less than about 1000 nm and are not rapidly soluble.
Claims19
-34. (canceled)
A pharmaceutical composition of submicron particles of precipitated paclitaxel or docetaxel comprising a suspension of precipitated small particles of an active agent, a phospholipid conjugated with a water-soluble or hydrophilic polymer, and a copolymer of oxyethylene and oxypropylene, the precipitated small particles having an average effective particle size of less than 1000 nm, and the active agent consisting of paclitaxel or docetaxel.
A pharmaceutical composition of submicron particles of precipitated paclitaxel or docetaxel comprising a dry powder of precipitated small particles of an active agent, a phospholipid conjugated with a water-soluble or hydrophilic polymer, and a copolymer of oxyethylene and oxypropylene, the precipitated small particles having an average effective particle size of less than 1000 nm, and the active agent consisting of paclitaxel or docetaxel.
Dependencies are inferred from the claim text.