Rhein or diacerein compositions
AssigneeWockhardt Limited
InventorsRahul Dabre, Girish Kumar Jain, Cyril Estanove, François Pruvost, Roshanlal Sandal, Prashant Mandaogade, Premchand Nakhat
Life of this patent
Estimating the term…
Abstract
The invention relates to pharmaceutical compositions comprising rhein or diacerein or salts or esters or prodrugs thereof, optionally with one or more pharmaceutically acceptable excipients. The invention also relates to the methods for preparing such compositions.
Claims36
A pharmaceutical composition comprising rhein or diacerein, or salts or esters or prodrugs thereof adsorbed on a pharmaceutically acceptable adsorbent.
A pharmaceutical composition comprising rhein or diacerein, or salts or esters or prodrugs thereof and one or more water-soluble cyclodextrins or derivatives thereof.
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A pharmaceutical composition comprising rhein or diacerein or salts or esters or prodrugs thereof and one or more sugar alcohols.
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A pharmaceutical composition comprising rhein or diacerein or salts or esters or prodrugs thereof characterized by the crystallographic data shown in FIG. 1.
A pharmaceutical composition comprising rhein or diacerein or salts or esters or prodrugs thereof thereof having X-ray diffraction peaks at angle 2 theta of 9.6 and 13.52 degrees.
A method of improving the solubility of diacerein or salts thereof, wherein the rhein or diacerein or salts or esters or prodrugs there of is associated with one or more sugar alcohols.
A process for the preparation of a pharmaceutical composition, the process comprising spraying a solution of rhein or diacerein or salts or esters or prodrugs thereof in one or more organic solvents, optionally with sugar alcohols and/or one or more pharmaceutically acceptable excipients in a flow of a fluid under supercritical pressure to form particles and collecting the particles.
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Dependencies are inferred from the claim text.