Anti-trypanosomal peptides and uses thereof
AssigneeUniversity of Georgia Research Foundation, Inc.
InventorsJohn M. Harrington, Stephen L. Hajduk
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Abstract
The present invention provides methods of killing, inhibiting the growth, and/or inhibiting the reproduction of kinetoplastid protozoan with hydrophobic signal sequence peptides and compositions including such hydrophobic signal sequence peptides.
Claims19
A method of killing a bloodstream form of a kinetoplastid protozoan of the genus Trypanosoma, the method comprising contacting the protozoan with a hydrophobic signal sequence peptide, wherein the hydrophobic signal sequence peptide consists of about 12 to about 25 amino acid residues, and wherein the hydrophobic signal sequence peptide contains a positively charged amino acid at position minus five relative to the C-terminus of the hydrophobic signal sequence peptide.
A method of treating or preventing a trypanosomal infection in a subject, the method comprising administering to the subject an effective amount of a hydrophobic signal sequence peptide, wherein the hydrophobic signal sequence peptide consists of about 12 to about 25 amino acid residues, and wherein the hydrophobic signal sequence peptide contains a positively charged amino acid at position minus five relative to the C-terminus of the hydrophobic signal sequence peptide.
A composition comprising a hydrophobic signal sequence peptide and a pharmaceutical carrier suitable for parenteral or enteral administration to a mammal, wherein the hydrophobic signal sequence peptide consists of about 12 to about 25 amino acid residues, and wherein the hydrophobic signal sequence peptide contains a positively charged amino acid at position minus five relative to the C-terminus of the hydrophobic signal sequence peptide.
Dependencies are inferred from the claim text.