Method of inducing neutralizing antibodies to human immunodeficiency virus
AssigneeDuke University
InventorsBarton F. Haynes, S. Munir Alam, Hua-Xin Liao, Leonard D. Spicer, Patrick N. Reardon
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Abstract
The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.
Claims13
A method of inducing the production in a patient of anti-HIV antibodies comprising administering to a patient in need thereof an amount of at least one liposome-peptide conjugate in an amount sufficient to effect said induction, wherein said peptide comprises a membrane external proximal region (MPER) epitope and said liposome comprises lysophosphorylcholine or phosphatidylserine.
An immunogen comprising an MPER epitope embedded in a liposome, wherein said liposome comprises lysophosphorylcholine or phosphatidylserine.
A method of treating HIV comprising administering to a patient in need thereof an antibody derivable from an normal subject or from an autoimmune disease subject that binds to a lipid on the surface of HIV or on the surface of HIV-infected cells and thereby neutralizes HIV-1, wherein said antibody is CL1, or antibody having the binding specificity thereof, or a binding fragment thereof, and is administered in an amount sufficient to effect said treatment.
An immunogenic conjugate comprising the transmembrane domain of HIV-1 gp41 and an MPER peptide, wherein said MPER peptide is anchored in a liposome via said transmembrane domain.
An immunogenic conjugate comprising foldon and an MPER peptide, wherein said MPER peptide is present as a trimer attached to a biological membrane mimetic.
Dependencies are inferred from the claim text.