Multi-Functional Biocompatible Coatings for Intravascular Devices
OwnerZhengrong Zhou, Mark E. Meyerhoff +1inventors
InventorsZhengrong Zhou, Mark E. Meyerhoff, Melissa M. Reynolds
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Abstract
A polymeric coating is adapted to substantially eliminate thrombus formation when in contact with blood. The polymeric coating includes a first polymeric layer and a second polymeric layer. Interposed between the first and second polymeric layers is a polymeric matrix layer doped with at least one of a nitric oxide donor and a nitric oxide generator. The nitric oxide donor and/or the nitric oxide generator are capable of releasing or generating NO. A bioactive agent is either immobilized to the surface of the second polymeric layer or is incorporated into the polymeric matrix layer.
Claims17
1-12. (canceled)
A polymeric coating for an intravascular device, comprising:
- a dense polymeric layer;
- a polymeric matrix layer disposed on the dense polymeric layer, the polymeric matrix layer doped with at least one of a nitric oxide donor and a nitric oxide generator, the at least one of the nitric oxide donor and the nitric oxide generator capable of at least one of releasing and generating NO;
- an aminated polymeric layer disposed on the polymeric matrix layer;
- and
- a bioactive agent immobilized to a surface of the aminated polymeric layer via at least one of ionic bonding and covalent bonding.
24-43. (canceled)
A method for forming a polymeric coating on an intravascular device, the method comprising:
- establishing a first polymeric layer on the device;
- doping a polymeric matrix layer with at least one of a nitric oxide donor and a nitric oxide generator, the at least one of the nitric oxide donor and the nitric oxide generator capable of at least one of releasing and generating NO;
- establishing the polymeric matrix layer on the first polymeric layer;
- establishing a second polymeric layer on the polymeric matrix layer;
- and
- establishing a bioactive agent via at least one of immobilization to a surface of the second polymeric layer and incorporation into the polymeric matrix layer;
- wherein the polymeric coating is adapted to substantially eliminate thrombus formation when in contact with blood.
47-53. (canceled)
Dependencies are inferred from the claim text.