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US 2012/0070473 A1Published application
Apparatus and Method for Reducing the Occurrence of Post-Surgical Adhesions
AssigneeAnhese LLC
InventorJohn P. Delaney
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AssigneeAnhese LLC
InventorJohn P. Delaney
Estimating the term…
A method for inhibiting formation of adhesions following abdominal surgery which involves application of an anti-static fatty acid ethoxylated amide (Cocamide DEA) in a matrix that is placed in the peritoneal cavity at the conclusion of an abdominal surgery and which releases this anti-adhesive chemical over a predetermined time in a range up to seven days. Tests conducted on laboratory rats established that the method reduced the incidence of adhesions from 100 percent (100%) in a test model to near zero in the majority of treated animals. In an alternative embodiment, andrographalide was delivered via a pump with similar results. In still another embodiment, an effective amount of 50% phosphatidylchorene and propylene glycol was delivered, via a pump, into the abdominal cavity, again with similar results.
A composition suitable for local administration of a drug into the peritoneal cavity following a surgical procedure, said composition comprising a 50% phosphatidylcholine plus propylene glycol in an amount effective to inhibit formation of post-operative adhesions upon intraperitoneal administration of said composition to tissues, throughout the peritoneal cavity in a carrier suitable for local prolonged administration of said composition with consequent minimal levels attained in the systemic circulation.
A composition suitable for local, non-systemic administration of a drug topically to tissue within the peritoneal cavity having been subjected to a surgical procedure, said composition comprising an andrographalide agent in an amount effective to inhibit formation of post-operative adhesions upon local, non-systemic administration of said anti-adhesive agent to intra-abdominal tissues, and a carrier suitable for local prolonged administration of said anti-adhesive agent with minimal systemic circulation.
A method of inhibiting formation of abdominal adhesions, post surgery, which comprises delivering an effective amount of andrographalide into the abdominal cavityver a predetermined time interval.
A composition suitable for local administration of a drug topically to tissue within the peritoneal cavity having been subjected to a surgical procedure, said composition comprising a cocamide DEA agent in an amount effective to inhibit formation of post-operative adhesions upon local, non-systemic administration of said anti-adhesive agent to intra-abdominal tissues, and a carrier suitable for local prolonged administration of said anti-adhesive agent with minimal systemic circulation.
Dependencies are inferred from the claim text.