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US 2012/0070469 A1Published application
Beta-casein assemblies for mucosal delivery of therapeutic bioactive agents
AssigneesTechnion Research & Development Foundation Limited, Yissum Research Development Company of the Hebrew University of Jerusalem
InventorsYechezkel BARENHOLZ, Dganit Danino
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Abstract
Nanoparticulate assemblies of isolated β-casein are useful for encapsulation of bioactive therapeutic substances, particularly therapeutic agents with poor bioavailability. The nanoparticulate assemblies can be freeze-dried and re-suspended prior to administration.
Claims26
A composition comprising micelles, assemblies or complexes thereof, wherein the micelles, assemblies or complexes thereof comprise:
- (1) β-casein;
- and (2) at least one therapeutic agent, wherein the composition is a dried composition, wherein said β-casein comprises at least about 70% of the total casein content, wherein said micelles, assemblies or complexes are formed in the absence of calcium ions.
Dependencies are inferred from the claim text.