Removal of toxins from gastrointestinal fluids
AssigneeUop LLC
InventorsRobert L. Bedard, Michael G. Gatter
Life of this patent
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Abstract
A process for the removal of toxic cations and anions from gastrointestinal fluids is disclosed. A pH-increasing medication is administered prior to or together with a microporous cation exchanger. An additional feature of the invention is the use of a proton form of the microporous cation exchanger. The acidity of the gastrointestinal fluids is decreased to improve the stability of the microporous cation exchangers, which are represented by the empirical formula: ApMxZr1-xSinGeyOm (I) or ApMxTi1-xSinGeyOm (II)
Claims23
A process for removing toxins from gastrointestinal fluid, the process comprising contacting the fluid with a shaped ion exchange composite at ion exchange conditions together with a pH-increasing medication, thereby providing a purified fluid, the composite comprising a mixture of a microporous cation exchange composition and an anion exchange composition, where the cation exchange composition is selected from the group consisting of zirconium metallate, titanium metallate and mixtures thereof, the metallates respectively having an empirical formula on an anhydrous basis of:
- ApMxZr1−xSinGeyOm (I)
- or
- ApMxTi1−xSinGeyOm (II)
- where A is an exchangeable cation selected from the group consisting of potassium ion, sodium ion, calcium ion, magnesium and mixtures thereof, M is at least one framework metal selected from the group consisting of hafnium (4+), tin (4+), niobium (5+), titanium (4+), cerium (4+), germanium (4+), praseodymium (4+), and terbium (4+), except that M is not titanium in formula (II), “p” has a value from about 1 to about 20, “x” has a value from zero to less than 1, “n” has a value from 0 to about 12, “y” has a value from 0 to about 12, “m” has a value from about 3 to about 36 and 1≦n+y≦12, and the anion exchange composition is selected from the group consisting of hydrous zirconium oxide, zirconia, alumina, titania, hydrous titanium oxide, layered double hydroxides, single phase metal oxide solid solutions, magnesium hydroxide, calcium hydroxide, silica, amorphous mixed metal oxides, basic clays and mixtures thereof.
A process for removing toxins from a mammalian body comprising enterally administering a microporous ion exchanger and a pH-increasing medication wherein the microporous ion exchanger is selected from the group consisting of zirconium metallate, titanium metallate and mixtures thereof, the metallates respectively having an empirical formula on an anhydrous basis of:
- ApMxZr1−xSinGeyOm (I)
- or
- ApMxTi1−xSinGeyOm (II)
- where A is an exchangeable cation selected from the group consisting of potassium ion, sodium ion, calcium ion, magnesium and mixtures thereof, M is at least one framework metal selected from the group consisting of hafnium (4+), tin (4+), niobium (5+), titanium (4+), cerium (4+), germanium (4+), praseodymium (4+), and terbium (4+), except that M is not titanium in formula (II), “p” has a value from about 1 to about 20, “x” has a value from zero to less than 1, “n” has a value from 0 to about 12, “y” has a value from 0 to about 12, “m” has a value from about 3 to about 36 and 1≦n+y≦12, and the anion exchange composition is selected from the group consisting of hydrous zirconium oxide, zirconia, alumina, titania, hydrous titanium oxide, layered double hydroxides, single phase metal oxide solid solutions, magnesium hydroxide, calcium hydroxide, silica, amorphous mixed metal oxides, basic clays and mixtures thereof and the pH-increasing medication is selected from the group consisting of antacids, alginic acid, histamine H2 receptor blockers, proton pump inhibitors and mixtures thereof.
A process for removing toxins from gastrointestinal fluid, the process comprising first administering a pH-increasing medication to a patient to increase the pH of the gastrointestinal fluid and then contacting the gastrointestinal fluid with a shaped ion exchange composite at ion exchange conditions, thereby providing a purified fluid, the composite comprising a mixture of a microporous cation exchange composition and an anion exchange composition, where the cation exchange composition is selected from the group consisting of zirconium metallate, titanium metallate and mixtures thereof, the metallates respectively having an empirical formula on an anhydrous basis of:
- ApMxZr1−xSinGeyOm (I)
- or
- ApMxTi1−xSinGeyOm (II)
- where A is an exchangeable cation selected from the group consisting of potassium ion, sodium ion, calcium ion, magnesium and mixtures thereof, M is at least one framework metal selected from the group consisting of hafnium (4+), tin (4+), niobium (5+), titanium (4+), cerium (4+), germanium (4+), praseodymium (4+), and terbium (4+), except that M is not titanium in formula (II), “p” has a value from about 1 to about 20, “x” has a value from zero to less than 1, “n” has a value from 0 to about 12, “y” has a value from 0 to about 12, “m” has a value from about 3 to about 36 and 1≦n+y≦12, and the anion exchange composition is selected from the group consisting of hydrous zirconium oxide, zirconia, alumina, titania, hydrous titanium oxide, layered double hydroxides, single phase metal oxide solid solutions, magnesium hydroxide, calcium hydroxide, silica, amorphous mixed metal oxides, basic clays and mixtures thereof.
Dependencies are inferred from the claim text.