Ophthalmic Drug Delivery
AssigneeCorinthian Ophthalmic, Inc.
InventorsBernard L. Ballou, JR., Mark Packer, Russell John Mumper, Tsontcho Inachulev
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Abstract
The present invention includes and provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.
Claims52
A method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising:
- (a) providing droplets containing said medicament, wherein said droplets have an average droplet size of at least about 15 microns and an average initial ejecting velocity between 1 m/s and 5 m/s;
- and
- (b) delivering said medicament to said eye, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye.
A method of delivering a medicament solution on the eye to a subject in need thereof by controlling average droplet size and deposit parameters of said medicament solution comprising:
- (a) determining desired dosage of said medicament solution for said subject in need thereof;
- and
- (b) providing said desired dosage in a single application by determining said average droplet size and deposit parameters of said medicament solution on the eye.
A method for providing a solution to the eye comprising:
- (a) providing droplets containing said medicament, wherein said droplets have an average droplet size of at least about 15 microns in diameter and an average initial ejecting velocity of between about 1 m/s and 5 m/s;
- and
- (b) delivering said medicament to said eye, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye.
A method of treating glaucoma in a subject in need there of comprising:
- (a) providing droplets containing said medicament, wherein said droplets have an average droplet size of at least about 15 micron in diameter and an average initial ejecting velocity of between about 1 m/s and 5 m/s;
- and
- (b) delivering said medicament to said eye, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye.
A method of treating an infection in a subject in need thereof, comprising:
- (a) providing droplets containing said medicament, wherein said droplets have an average droplet size of at least about 15 microns in diameter and an average initial ejecting velocity of between about 1 m/s and about 5 m/s;
- and
- (b) delivering said medicament to said eye, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye.
A method of providing a reduced dosage form of a medicament to an eye comprising:
- (a) providing droplets containing said medicament, wherein said droplets have an average droplet size of at least about 15 microns in diameter and an average initial ejecting velocity of between 1 m/s and 5 m/s;
- and
- (b) delivering said medicament to said eye, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye, and wherein said droplets provide a total volume of less than 30 μl to said eye.
Dependencies are inferred from the claim text.