Conjugated Polymeric Material and Uses Thereof
AssigneeUniversity of Missouri, Office of Ipa
InventorsAnthony Harris, Jonathan Thompson, Rebecca Rone, Sheila Grant, David Grant
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Abstract
Disclosed are compositions comprising collagen covalently bound to particles, wherein covalent bonds are formed between reactive groups of the collagen and reactive groups of the particles, and wherein the particles have an average particle diameter ranging from 20 to 1000 nanometers. Also disclosed are various methods that utilize the compositions.
Claims32
A composition comprising collagen covalently bound to particles, wherein covalent amide bonds are formed between free carboxylic acid groups of the collagen and amine reactive groups of the particles, and wherein the particles have an average particle diameter size ranging from 50 to 1000 nanometers.
A method of reducing collagen degradation in vitro or in vivo by enzymatic breakdown comprising conjugating collagen with particles having reactive amine groups and having an average particle diameter ranging from 50-1000 nanometers, wherein covalent amide bonds are formed between free carboxylic acid groups of the collagen and the reactive amine groups on the particles, and wherein degradation of the collagen by collagenase is thereby reduced.
Dependencies are inferred from the claim text.