Dengue vaccine, pharmaceutical composition comprising the same, nucleotide sequence and antibody composition
AssigneeNational Cheng Kung University
InventorYee-Shin Lin
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Abstract
The present invention relates to a dengue vaccine, a pharmaceutical composition comprising the same, a nucleotide sequence, and an antibody composition. The dengue vaccine of the present invention includes chimeric nonstructural protein 1, which comprises N-terminus of DV NS1 from amino-acid residues 1 to 270 and C-terminus of JEV NS1 from amino-acid residues 271 to 352 (designated DJ NS1). Therefore, the dengue vaccine without autoimmunity according to the present invention is able to avoid cross-reactions with endothelial cells and platelets, and is able to shorten the bleeding time.
Claims18
A dengue vaccine comprising a chimeric nonstructural protein DJ NS1, wherein the chimeric nonstructural protein DJ NS1 comprises:
- N-terminus of dengue virus nonstructural protein 1 (DV NS1) from amino acids 1 to 270;
- and
- C-terminus of Japanese encephalitis virus nonstructural protein 1 (JEV NS1) from amino acids 271 to 352.
A dengue vaccine-containing pharmaceutical composition, wherein the dengue vaccine comprises a chimeric nonstructural protein DJ NS1, and the chimeric nonstructural protein DJ NS1 comprises:
- N-terminus of dengue virus nonstructural protein 1 (DV NS1) from amino acids 1 to 270;
- and
- C-terminus of Japanese encephalitis virus nonstructural protein 1 (JEV NS1) from amino acids 271 to 352.
A nucleotide sequence which encodes a chimeric nonstructural protein DJ NS1, wherein the chimeric nonstructural protein DJ NS1 comprises:
- N-terminus of dengue virus nonstructural protein 1 (DV NS1) from amino acids 1 to 270;
- and
- C-terminus of Japanese encephalitis virus nonstructural protein 1 (JEV NS1) from amino acids 271 to 352.
An antibody composition for binding to a chimeric nonstructural protein DJ NS1, wherein the chimeric nonstructural protein 1 DJ NS1 comprises:
- N-terminus of dengue virus nonstructural protein 1 (DV NS1) from amino acids 1 to 270;
- and
- C-terminus of Japanese encephalitis virus nonstructural protein 1 (JEV NS1) from amino acids 271 to 352.
Dependencies are inferred from the claim text.