Methods and compositions for modulating cardiac contractility
AssigneeConsiglio Nazionale Delle Ricerche
InventorsGianluigi Condorelli, Deniele Catalucci
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Abstract
Provide is a Cavβ2 peptide or variant thereof, or synthetic molecules, or polynucleotides encoding said peptide or variant, for use in the modulation of cardiac inotropism. Also provided are compositions and methods of treatment comprising said Cavβ2 peptide, polynucleotide or variants thereof.
Claims21
1-23. (canceled)
A method of treatment or prophylaxis, comprising administering to a subject a Cavβ2 peptide or variant thereof, or a polynucleotide encoding the Cavβ2 peptide or variant thereof, wherein the subject is a subject in need of modulation of cardiac inotropism.
A protein or polynucleotide, comprising a PEST-binding factor, which is capable of binding to a PEST sequence of a Cavα1 polypeptide and preventing the degradation of the Cavα1 polypeptide.
A polypeptide, comprising a variant of a Cavα1 polypeptide, in which either the I-II (Cavα1-ΔP) or II-III (Cavα1-ΔH) cytosolic linker region of the Cavα1 polypeptide has been mutated.
Dependencies are inferred from the claim text.