Methods of treating inflammation
AssigneeYeda Research and Development Co. Ltd.
InventorsIdit Shachar, Einat Toister
Life of this patent
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Abstract
A method of treating an inflammation in a subject in need thereof is disclosed. The method comprising administering to the subject an agent capable of down-regulating an activity or expression of CD151 in a lymphocyte, with the proviso that the agent is not CCL2, thereby treating the inflammation.
Claims27
A method of treating an inflammation in a subject in need thereof, the method comprising administering to the subject a peptide capable of downregulating an activity of CD151 in a lymphocyte, thereby treating the inflammation.
2-3. (canceled)
A pharmaceutical composition comprising as an active ingredient a peptide capable of downregulating an activity of CD151 in a lymphocyte, and a pharmaceutically acceptable carrier.
5-14. (canceled)
(canceled)
A method of treating an inflammation in a subject in need thereof, the method comprising administering to the subject a CD151 blocking antibody capable of downregulating an activity of CD151 in a lymphocyte, with the proviso that said inflammation is not cancer, thereby treating the inflammation.
A method of inhibiting lymphocyte migration or homing in a subject in need thereof, the method comprising administering to the subject a peptide capable of downregulating an activity of CD151 in said lymphocyte, thereby inhibiting said lymphocyte migration or homing.
A method of inhibiting lymphocyte migration or homing in a subject in need thereof, the method comprising administering to the subject a CD151 blocking antibody capable of downregulating an activity of CD151 in said lymphocyte, thereby inhibiting said lymphocyte migration or homing.
A pharmaceutical composition comprising as an active ingredient a CD151 blocking antibody capable of downregulating an activity of CD151 in a lymphocyte and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.