Rsv specific binding molecule
AssigneeAimm Therapeutics B.V.
InventorsTIM BEAUMONT, ADRIANUS Q. BAKKER, ETSUKO YASUDA
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Abstract
The invention provides antibodies and functional equivalents thereof which are capable of specifically binding RSV. Nucleic acid sequences encoding said antibody, as well as antibody producing cells and methods for producing said antibody are also provided.
Claims20
-28. (canceled)
An isolated antibody or a functional part thereof that binds to a respiratory syncytial virus (RSV) F protein, wherein the antibody or functional part thereof comprises:
- (a) a heavy chain complementarity determining region (CDR) 1 comprising the amino acid sequence KLSIH (SEQ ID NO:
- 4), a heavy chain CDR2 comprising the amino acid sequence GYEGEVDEIFYAQKFQH (SEQ ID NO:
- 8), a heavy chain CDR3 comprising the amino acid sequence LGVTVTEAGLGIDDY (SEQ ID NO:
- 12), a light chain CDR1 comprising the amino acid RASQIVSRNHLA (SEQ ID NO:
- 20), a light chain CDR2 comprising the amino acid sequence GASSRAT (SEQ ID NO:
- 24), and a light chain CDR3 comprising the amino acid sequence LSSDSSI (SEQ ID NO:
- 28);
- (b) a heavy chain sequence comprising the amino acid sequence of SEQ ID NO:
- 16;
- (c) a light chain sequence comprising the amino acid sequence of SEQ ID NO:
- 32;
- or
- (d) a heavy chain sequence comprising the amino acid sequence of SEQ ID NO:
- 16 and a light chain sequence comprising the amino acid sequence of SEQ ID NO:
- 32.
An isolated antibody or a functional part thereof that specifically binds to the epitope of a RSV F protein that is recognized by a reference antibody, wherein the reference antibody comprises a heavy chain CDR1 comprising the amino acid sequence KLSIH (SEQ ID NO:
- 4), a heavy chain CDR2 comprising the amino acid sequence GYEGEVDEIFYAQKFQH (SEQ ID NO:
- 8), a heavy chain CDR3 comprising the amino acid sequence LGVTVTEAGLGIDDY (SEQ ID NO:
- 12), a light chain CDR1 comprising the amino acid RASQIVSRNHLA (SEQ ID NO:
- 20), a light chain CDR2 comprising the amino acid sequence GASSRAT (SEQ ID NO:
- 24), and a light chain CDR3 comprising the amino acid sequence LSSDSSI (SEQ ID NO:
- 28).
An isolated nucleic acid sequence comprising:
- (a) a nucleotide sequence encoding a heavy chain CDR1, a nucleotide sequence encoding a heavy chain CDR2, a nucleotide sequence encoding a heavy chain CDR3, a nucleotide sequence encoding a light chain CDR1, a nucleotide sequence encoding a light chain CDR2, and a nucleotide sequence encoding a light chain CDR3 of an antibody or a functional part thereof that binds to a RSV F protein, wherein the heavy chain CDR1 comprises the amino acid sequence KLSIH (SEQ ID NO:
- 4), the heavy chain CDR2 comprises the amino acid sequence GYEGEVDEIFYAQKFQH (SEQ ID NO:
- 8), the heavy chain CDR3 comprises the amino acid sequence LGVTVTEAGLGIDDY (SEQ ID NO:
- 12), the light chain CDR1 comprises the amino acid RASQIVSRNHLA (SEQ ID NO:
- 20), the light chain CDR2 comprises the amino acid sequence GASSRAT (SEQ ID NO:
- 24), and the light chain CDR3 comprises the amino acid sequence LSSDSSI (SEQ ID NO:
- 28);
- (b) a nucleotide sequence encoding a heavy chain sequence of an antibody or a functional part thereof that binds to a RSV F protein, wherein the heavy chain sequence comprises the amino acid sequence of SEQ ID NO:
- 16;
- (c) a nucleotide sequence encoding a light chain sequence of an antibody or a functional part thereof that binds to a RSV F protein, wherein the heavy chain sequence comprises the amino acid sequence of SEQ ID NO:
- 32;
- or
- (d) a nucleotide sequence encoding a heavy chain sequence and a nucleotide sequence encoding a light chain sequence of an antibody or a functional part thereof that binds to a RSV F protein, wherein the heavy chain sequence comprises the amino acid sequence of SEQ ID NO:
- 16 and the light chain sequence comprises the amino acid sequence of SEQ ID NO:
- 32.
Dependencies are inferred from the claim text.