Antigen-binding proteins
OwnerRichard Lewis Easeman, Jonathan Henry Ellis +1inventors
InventorsRichard Lewis Easeman, Jonathan Henry Ellis, Paul Andrew Hamblin
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Abstract
The present invention relates to antigen binding proteins comprising a receptor-Fc fusion which is linked to one or more epitope-binding domains, methods for making such proteins, and uses thereof.
Claims27
An antigen-binding protein comprising a receptor-Fc fusion which is linked to one or more epitope-binding domains.
The antigen-binding protein of any preceding claim wherein the binding protein has specificity for more than one antigen.
The antigen-binding protein according to any preceding claim wherein the receptor-Fc fusion comprises CTLA-4-Ig.
The antigen-binding protein according to any preceding claim wherein the receptor-Fc fusion comprises TNFR2-Ig.
The antigen-binding protein according to any preceding claim wherein the receptor-Fc fusion comprises TACI-Ig.
The antigen-binding protein according to any preceding claim wherein at least one epitope binding domain is capable of binding VEGF or VEGFR2.
The antigen-binding protein according to any preceding claim wherein at least one epitope binding domain is capable of binding TNFα.
The antigen-binding protein according to any preceding claim wherein at least one epitope binding domain is capable of binding HER2.
The antigen-binding protein according to any preceding claim wherein at least one of the epitope binding domains is directly attached to the receptor-Fc fusion with a linker comprising from 1 to 150 amino acids.
The antigen-binding protein according to any preceding claim wherein at least one of the epitope binding domains binds human serum albumin.
The antigen-binding protein according to any preceding claim comprising an epitope binding domain attached to the N-terminus of the Receptor-Fc fusion.
The antigen-binding protein according to any preceding claim comprising an epitope binding domain attached to the C-terminus of the Receptor-Fc fusion
A recombinant transformed or transfected host cell comprising one or more polynucleotide sequences encoding an antigen-binding protein of any preceding claim.
The antigen-binding protein according to any preceding claim for use in medicine.
The antigen-binding protein according to any preceding claim for use in the manufacture of a medicament for treating immune diseases for example auto-immune diseases, or cancer, or inflammatory diseases, for example systemic lupus erythramatosis, multiple sclerosis, crohns disease, psoriasis, or arthritic diseases, for example rheumatoid arthritis.
Dependencies are inferred from the claim text.