Chimeric antigens for eliciting an immune response

A chimeric antigen for eliciting an immune response, said chimeric antigen comprising:

• an immune response domain, wherein the immune response domain comprises one or more immunogenic portions of one or more proteins selected from the group consisting of a HCV E1 protein, a HCV E2 protein, a HCV E1-E2 protein, a HCV NS3 protein, a HCV NS4B protein, and a HCV NS5A protein, and a combination thereof.
• a target binding domain comprising a xenotypic antibody fragment, wherein the antibody fragment is an Fc antibody fragment.

A method of producing a chimeric antigen comprising:

• (a) providing a microorganism or a cell, the microorganism or cell comprising a
• (b) culturing said microorganism or cell under conditions whereby the chimeric antigen is expressed.

A polynucleotide encoding a chimeric antigen, said polynucleotide comprising a first polynucleotide portion encoding an immune response domain and a second polynucleotide portion encoding a target binding domain, wherein the target binding domain comprises an antibody fragment.