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AssigneeMacroGenics, Inc.
InventorsLeslie S. Johnson, Ling Huang
Estimating the term…
The present invention relates to compositions comprising humanized antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV) and methods for preventing, treating or ameliorating symptoms associated with a flavivirus, particularly of West Nile Virus (WNV) infection utilizing said compositions. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with WNV infection, said methods comprising administering to a human subject an effective amount of one or more humanized antibodies or fragments thereof that immunospecifically bind to a WNV antigen. The present invention also relates to detectable or diagnostic compositions comprising humanized antibodies or fragments thereof that immunospecifically bind to a WNV antigen and methods for detecting or diagnosing WNV infection utilizing said compositions.
-16. (canceled)
A method for prophylactic treatment of a West Nile Virus (WNV) infection in a patient, said method comprising administering to said patient a prophylactically effective amount of a humanized antibody or an epitope binding fragment thereof comprising three VH complementary determining regions (CDRs) and three VL CDRs,
Dependencies are inferred from the claim text.