HCV Inhibitor and Therapeutic Agent Combinations

A combination product for treating or ameliorating HCV (hepatitis C virus) infection or disorders or symptoms associated therewith in a subject in need thereof comprising, a HCV inhibitor compound of Formula (I) or a free acid, free base, salt, hydrate, solvate, clathrate, isotopologue, racemate, enantiomer, diastereomer, stereoisomer or polymorph form thereof:

• wherein
• X is hydrogen, halogen, cyano, nitro, carboxyl, C1-8alkyl-carbonyl, C1-8alkoxy-carbonyl, formyl, amino, C1-8alkyl-amino, amino-carbon C1-8alkyl-amino-carbonyl or C1-8alkyl-sulfonyl;
• Ar is heteroaryl or heterocyclyl, each optionally substituted with one or two substituents independently selected from halogen, C1-8alkyl, halo-C1-8alkyl, C1-8alkoxy, halo-C1-8alkoxy, amino or C1-8alkyl-amino;
• Z is C1-8alkyl, C2-8alkenyl-C1-8alkyl, C2-8alkyl-C1-8alkyl, halo-C1-8alkyl, C1-8alkoxy-C1-8alkyl, C1-8alkoxy-carbonyl, carbonyl, C3-14cycloalkyl, C3-14cycloalkenyl, C3-14cycloalkyl-C1-8alkyl, aryl, aryl-C1-8alkyl, heteroaryl heteroaryl-C1-8alkyl, heterocyclyl or heterocyclyl-C1-8alkyl, wherein each instance of aryl and heteroaryl is optionally substituted with one, two, three or four substituents each selected from hydroxy, cyano, nitro, halogen, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, hydroxy-C1-8alkyl, halo-C1-8alkyl, C1-8alkoxy, halo-C1-8alkoxy, amino, C1-8alkyl-amino, C1-8alkoxy-C1-8alkyl, C1-8alkylthio, C1-8alkyl-carbonyl, C1-8alkoxy-carbonyl, C1-8alkyl-carbonyloxy, or amino-sulfonyl;
• R1 is —N(R3)—SO2—R4, —N(R3)—SO2—N(R5)—R6, —SO2—N(R5)—R6 or —SO2—R7;
• R2 is one two three or four substituents each selected from hydrogen, halogen, hydroxy, cyano, nitro, C1-8alkyl, hydroxy-C1-8alkyl, halo-C1-8alkyl, C2-8alkenyl, halo-C2-8alkenyl, C1-8alkoxy, halo-C1-8alkoxy, C1-8alkoxy-C1-8alkyl, C1-8alkyl-carbonyl, C1-8alkoxy-carbonyl, C1-8alkyl-carbonyloxy, C1-8alkyl-carbonyloxy-C1-8alkyl, C1-8alkyl-carbonyloxy-C1-8alkoxy, amino, C1-8alkyl-amino, amino-C1-8alkyl, C1-8alkyl-amino-C1-8alkyl, amino-C1-8alkoxy, C1-8alkyl-amino-C1-8alkoxy, C1-8alkoxy-C1-8alkyl-amino-C1-8alkoxy, amino-C1-8alkyl-amino-C1-8alkoxy, C1-8alkyl-amino-C1-8alkyl-amino-C1-8alkoxy, C1-8alkoxy-carbonyl-amino, carboxyl-amino, amino-carbonyl, amino-carbonyl-amino, C1-8alkyl-amino-carbonyl-amino, C1-8alkylthio, C1-8alkyl-sulfinyl, C1-8alkyl-sulfonyl, C1-8alkyl-sulfonyl-amino, C3-14cycloalkyl, C3-14cycloalkyl-C1-8alkyl, C3-14cycloalkyl-C1-8alkoxy, C3-14cycloalkyloxy, aryl, aryl-C1-8alkyl, aryl-C1-8alkoxy, aryloxy, aryl-carbonyl-amino, heteroaryl, heteroaryl-C1-8alkyl, heteroaryl-C1-8alkoxy, heteroaryloxy, heterocyclyl, heterocyclyl-C1-8alkyl, heterocyclyl-C1-8alkoxy, heterocyclyloxy or heterocyclyl-carbonyloxy, wherein each instance of C3-14cycloalkyl, aryl, heteroaryl and heterocyclyl is optionally substituted with one, two, three or four substituents each selected from halogen, cyano, C1-8alkyl, C1-8alkoxy, C1-8alkoxy-C1-8alkyl, amino, C1-8alkyl-amino, amino-C1-8alkyl or C1-8alkyl-amino-C1-8alkyl;
• R3 is hydrogen or C1-8alkyl, optionally substituted on C1-8alkyl with one or more substituents each selected from halogen, hydroxy, cyano, C1-8alkoxy, amino or C1-8alkyl-amino;
• R4 is C1-8alkyl, halo-C1-8alkyl, C1-8alkoxy, halo-C1-8alkoxy, C3-14cycloalkyl, C3-14cycloalkyl-C1-8alkyl, aryl, aryl-C1-8alkyl, heteroaryl, heteroaryl-C1-8alkyl, heterocyclyl or heterocyclyl-C1-8alkyl, wherein each instance of aryl, heteroaryl, heterocyclyl and C3-14cycloalkyl is optionally substituted with one or two substituents each selected from halogen, C1-8alkyl, halo-C1-8alkyl, C1-8alkoxy, halo-C1-8alkoxy, amino or C1-8alkyl-amino;
• R5 is hydrogen, C1-8alkyl, C1-8alkyl-carbonyl- or C3-14cycloalkyl, optionally substituted on C1-8alkyl with one or more substituents each selected from halogen, hydroxy, cyano, or C1-8alkoxy;
• R6 is hydrogen, C1-8alkyl, hydroxy-C1-8alkyl, halo-C1-8alkyl, cyano-C1-8alkyl, C1-8alkoxy-C1-8alkyl, amino-C1-8alkyl, C1-8alkyl-amino-C1-8alkyl, C1-8alkyl-carbonyl, C1-8alkoxy-carbonyl, C3-14cycloalkyl, C3-14cycloalkyl-C1-8alkyl, aryl, aryl-C1-8alkyl, heteroaryl, heteroaryl-C1-8alkyl, heterocyclyl or heterocyclyl-C1-8alkyl, wherein each instance of aryl, heteroaryl, heterocyclyl and C3-14cycloalkyl is optionally substituted with one or two substituents each selected from halogen, C1-8alkyl, halo-C1-8alkyl, C1-8alkoxy, halo-C1-8alkoxy, amino or C1-8alkyl-amino;
• and
• R7 is C1-8alkyl, C3-14cycloalkyl, C3-14cycloalkyl-C1-8alkyl, aryl, aryl-C1-8alkyl, heteroaryl, heteroaryl-C1-8alkyl, heterocyclyl or heterocyclyl-C1-8alkyl, each instance of aryl, heteroaryl, C3-14cycloalkyl and heterocyclyl is optionally substituted with one or two substituents each selected from halogen, C1-8alkyl, halo-C1-8alkyl, C1-8alkoxy, amino or C1-8alkyl-amino
• and one or more therapeutic agents selected from either or both a HCV protease inhibitor and one or more different therapeutic agents administered in combination in an effective amount to the subject.