Methods and compositions for treating lupus
AssigneeGenzyme Corporation
InventorsJohanne M. Kaplan, Bruce L. Roberts, William M. Siders
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Abstract
The invention provides methods of treating lupus in a patient with an anti-CD52 antibody. Also includes are methods of increasing infiltration of regulatory T cells to affected sides of the patient's body, methods of reducing urine protein and/or albumin levels and methods of depleting lymphocytes to alleviate lupus symptoms.
Claims22
A method of increasing FoxP3+ regulatory T cells in a patient with lupus, comprising administering to the patient a therapeutically effective amount of an anti-CD52 antibody.
A method of reducing the level of urine protein, or urine albumin, or both, in a patient with lupus, comprising administering to the patient a therapeutically effective amount of an anti-CD52 antibody.
8-13. (canceled)
A method of treating a patient with lupus, comprising (a) administering to the patient an anti-CD52 antibody, and (b) administering to the patient an agent that stimulates FoxP3+ regulatory T cells.
A kit for treating lupus, comprising an anti-CD52 antibody, and an agent that stimulates FoxP3+ regulatory T cell.
21-23. (canceled)
Dependencies are inferred from the claim text.