Methods for identifying treatments that treat and/or prevent uv irradiation inducing photoaging
AssigneeThe Regents of the University of Michigan
InventorsGary J. Fisher, Yiru Xu, John J. Voorhees
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Abstract
Methods are provided for ascertaining and measuring RPTP-κ activity in response to insults such as UV irradiation and with respect to administration of a treatment and/or composition. Attenuation of EGFR activity by RPTP-κ affects aspects of photoaging, including damage to the skin, suppression of the immune system, DNA damage, and connective tissue degradation. Intervention with respect to the effects of photoaging can include protection of RPTP-κ from oxidation. The methods can be used for discovery of anti-aging treatments, adjuncts, or other preventative treatments, such as sunscreens.
Claims16
A method for preventing photoaging of a cell comprising inhibiting the oxidation of receptor protein tyrosine phosphatase-kappa (RPTP-κ).
Dependencies are inferred from the claim text.