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US 2012/0070382 A1Published application
Fluorescent conjugated polymers with a bodipy-based backbone and uses thereof
AssigneeMichigan Technological University
InventorHaiying Liu
Life of this patent
Estimating the term…
Abstract
The present invention provides various fluorescent conjugated polymers with a BODIPY-based backbone. The invention also provides methods of using the polymers of the invention, such as for imaging and detection of cells, tumors, bacteria and viruses.
Claims29
A polymer is according to formula (I):
- wherein each -A- is independently selected from -AR—, AR, AR, or AR;
- wherein each -AR— is independently selected from arylene or heteroarylene;
- wherein each R3 is independently selected from R, alkyl, aryl or heteroaryl
- wherein each R2 and R4 are independently selected from alkyl or H;
- wherein each R1 and R5 are independently selected from hydrogen, alkyl,
- or AR;
- wherein each R0 is —F, —OR, —R, aryl, heteroaryl, R, -Aryl, or -Heteroaryl;
- wherein each R is independently selected from —H, —(CH2)mR10, —(CH2)mCOO(CH2)pCH3, —(CH2)mSO3Na, —(CH2)mPO3Na, —(CH2)mN(CH3)3+Br−, —(CH2)mCOH(CH2)pCH3, —(CH2)mOR10, —(CH2)mOR8, —CH2CH2(OCH2CH2)mOR10, —CH2CH2(OCH2CH2)mOR8, —CH2CH2(OCH2CH2)mSR8, or
- and
- wherein each R8 is independently selected from a carbohydrate residue;
- and wherein each R10 is independently selected from hydrogen, alkyl, heteroalkyl, hydroxy, amino, ammonic acid, thiol, carboxylic acid, nitrile, azide, ethynylene, halo, and tosylate;
- wherein m is from 0 to 100;
- wherein n is from 2 to 300 and
- wherein p is from 0 to 20.
11 more elements
A polymer according to formula (II):
- wherein each -A- is independently selected from -AR—, AR, AR, or AR;
- wherein each -AR— is independently selected from arylene or heteroarylene;
- wherein each R3 is independently selected from R, alkyl, aryl or heteroaryl
- wherein each R2 and R4 are independently selected from alkyl or H;
- wherein each R6 is independently selected from H or alkyl;
- wherein each R0 is —F, —OR, —R, aryl, heteroaryl, R, -Aryl, or -Heteroaryl;
- wherein each R is independently selected from —H, —(CH2)mR10, —(CH2)mCOO(CH2)pCH3, —(CH2)mSO3Na, —(CH2)mPO3Na, —(CH2)mN(CH3)3+Br−, —(CH2)mCOH(CH2)pCH3, —(CH2)mOR10, —(CH2)mOR8, —CH2CH2(OCH2CH2)mOR10, —CH2CH2(OCH2CH2)mOR8, —CH2CH2(OCH2CH2)mSR8, or
- and
- wherein each R8 is independently selected from a carbohydrate residue;
- and wherein each R10 is independently selected from hydrogen, alkyl, heteroalkyl, hydroxy, amino, ammonic acid, thiol, carboxylic acid, nitrile, azide, ethynylene, halo, and tosylate;
- wherein m is from 0 to 100;
- wherein n is from 2 to 300 and
- wherein p is from 0 to 20.
10 more elements
A polymer according to formula (III):
- wherein each -A- is independently selected from -AR—, AR, AR, or AR;
- wherein each -AR— is independently selected from arylene or heteroarylene;
- wherein each R3 is independently selected from R, alkyl, aryl or heteroaryl
- wherein each R2 and R4 are independently selected from alkyl or H;
- wherein each R6 is independently selected from H or alkyl;
- wherein each R0 is —F, —OR, —R, aryl, heteroaryl, R, -Aryl;
- or -Heteroaryl;
- wherein each R is independently selected from —H, —(CH2)mR10, —(CH2)mCOO(CH2)pCH3, —(CH2)mSO3Na, —(CH2)mPO3Na, —(CH2)mN(CH3)3+Br−, —(CH2)mCOH(CH2)pCH3, —(CH2)mOR10, —(CH2)mOR8, —CH2CH2(OCH2CH2)mOR10, —CH2CH2(OCH2CH2)mOR8, —CH2CH2(OCH2CH2)mSR8, or
- and
- wherein each R8 is independently selected from a carbohydrate residue;
- and wherein each R10 is independently selected from hydrogen, alkyl, heteroalkyl, hydroxy, amino, ammonic acid, thiol, carboxylic acid, nitrile, azide, ethynylene, halo, and tosylate;
- wherein m is from 0 to 100;
- wherein n is from 2 to 300 and
- wherein p is from 0 to 20.
11 more elements
A polymer according to formula (IV):
- wherein each -A- is independently selected from -AR—, AR, AR, or AR,
- wherein each -AR— is independently selected from arylene or heteroarylene;
- wherein each R3 is independently selected from R, alkyl, aryl or heteroaryl
- wherein each R2 and R4 are independently selected from alkyl or H;
- wherein each R6 is independently selected from H or alkyl;
- wherein each R0 is —F, —OR, —R, aryl, heteroaryl, R, -Aryl, or -Heteroaryl;
- wherein each R is independently selected from —H, —(CH2)mR10, —(CH2)mCOO(CH2)pCH3, —(CH2)mSO3Na, —(CH2)mPO3Na, —(CH2)mN(CH3)3+Br−, —(CH2)mCOH(CH2)pCH3, —(CH2)mOR10, —(CH2)mOR8, —CH2CH2(OCH2CH2)mOR10, —CH2CH2(OCH2CH2)mOR8, —CH2CH2(OCH2CH2)mSR8, or
- and
- wherein each R8 is independently selected from a carbohydrate residue;
- and wherein each R10 is independently selected from hydrogen, alkyl, heteroalkyl, hydroxy, amino, ammonic acid, thiol, carboxylic acid, nitrile, azide, ethynylene, halo, and tosylate;
- wherein m is from 0 to 100;
- wherein n is from 2 to 300 and
- wherein p is from 0 to 20.
10 more elements
Dependencies are inferred from the claim text.