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US 2012/0070377 A1Published application
Compounds and biological materials and uses thereof
OwnerGokhan Yahioglu, Ioanna Stamati +1inventors
InventorsGokhan Yahioglu, Ioanna Stamati, Mahendra Deonarain
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Abstract
The invention provides compounds of Formula (I): wherein b, D, R1, R2, G, Ra and Rb have meanings given in the description, or pharmaceutically-acceptable salts or solvates, or pharmaceutically functional derivatives thereof. The invention further provides process for conjugating the compounds to carrier molecules and uses of such compounds and conjugates in the treatment of disease.
Claims53
A compound of Formula I:
- wherein:
- when b represents a double bond, D represents —CH2— or Q, Ra and Rb are both not present;
- when b represents a single bond, D represents —C(O)—, —CH2— or Q, Ra and Rb are either both H or both —OH;
- when R1 represents H or a moiety containing a functional group that can react with carboxyl, hydroxyl, amino or thiol group,
- R2 represents a H or solubilising group;
- or
- when R1 represents H or a solubilising group,
- R2 represents H or a moiety containing a functional group that can react with carboxyl, hydroxyl, amino or thiol group;
- G represents O or a direct bond;
- Q represents a structural fragment of formula Ig or Ih,
- or a pharmaceutically-acceptable salt or solvate, or a pharmaceutically functional derivative thereof.
8 more elements
-64. (canceled)
-67. (canceled)
Dependencies are inferred from the claim text.