Back to results
US 2012/0067815 A1Published application
Hybrid bioartificial kidney
AssigneeGambro Lundia AB
InventorsDavid Luttropp, Bernd Krause, Markus Neubauer, Reinhold Deppisch, Doris Deppisch, Andrea Schnell, Helmut Geiger, Juergen Bereiter-Hahn, Patrick Baer
Life of this patent
Estimating the term…
Abstract
A bioartificial kidney equivalent and a process for producing the bioartificial kidney equivalent. The hybrid bioartificial kidney comprises human proximal and distal renal tubule cells grown on particular synthetic membranes.
Claims20
A device comprising
- a) a first unit for at least one of hemodialysis, hemofiltration and hemodiafiltration of blood;
- and,
- b) a second unit for processing blood and dialysate from the first unit, the second unit comprising
- i) a plurality of permselective hollow fiber membranes lined with human proximal renal tubule cells, and
- ii) a plurality of permselective hollow fiber membranes lined with human distal renal tubule cells.
2 more elements
A method of treatment of at least one of acute and chronic renal failure, the method comprising preparing a device comprising
- a) a first unit for at least one of hemodialysis, hemofiltration and hemodiafiltration of blood;
- and,
- b) a second unit for processing blood and dialysate from the first unit, the second unit comprising
- i) a plurality of permselective hollow fiber membranes lined with human proximal renal tubule cells, and
- ii) a plurality of permselective hollow fiber membranes lined with human distal renal tubule cells, and
- performing the at least one of hemodialysis, hemofiltration and hemodiafiltration of blood with the first unit, and processing blood and dialysate from the first unit with the second unit.
3 more elements
A bioartificial kidney equivalent comprising a device comprising
- a) a first unit for at least one of hemodialysis, hemofiltration and hemodiafiltration of blood;
- and,
- b) a second unit for processing blood and dialysate from the first unit, the second unit comprising
- i) a plurality of permselective hollow fiber membranes lined with human proximal renal tubule cells, and
- ii) a plurality of permselective hollow fiber membranes lined with human distal renal tubule cells.
2 more elements
A process for the extracorporeal treatment of blood, comprising:
- (a) subjecting said blood to at least one of hemodialysis, hemofiltration and hemodiafiltration, thereby producing processed blood and a dialysate;
- (b) conducting said dialysate through the intracapillary space of a plurality of permselective hollow fiber membranes lined with human proximal renal tubule cells, while circulating said processed blood on the outside of said permselective hollow fiber membranes;
- (c) conducting said dialysate through the intracapillary space of a plurality of permselective hollow fiber membranes lined with human distal renal tubule cells, while circulating said processed blood on the outside of said permselective hollow fiber membranes.
Dependencies are inferred from the claim text.