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US 2012/0065392 A1Published application
Method for preparing meropenem using zinc powder
AssigneesDaewoong Bio Inc., Daewoong Pharmaceutical Co., Ltd.
InventorsYoon Seok Song, Sung Woo Park, Yeon Jung Yoon, Hee Kyoon Yoon, Seong Cheol Moon, Byung Goo Lee, Soo Jin Choi, Sun Ah Jun
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Abstract
The present invention relates to an improved method for synthesizing meropenem trihydrate [(1R,5S,6S)-2-[((2′S,4′S)-2′-dimethylaminocarbozyl)pyrrolidin-4′-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid, trihydrate], which is a novel carbapenem antibiotic.
Claims20
-19. (canceled)
A method for preparing meropenem trihydrate of formula (1):
- comprising:
- a. reacting meropenem-PNB of formula (2)
- with zinc powder in a mixture solvent comprised of an organic solvent and an aqueous phosphate solution to remove p-nitrobenzyl from said meropenem-PNB;
- b. removing phosphate from the mixture resulting from step a;
- and
- c. crystallizing meropenem trihydrate by the addition of a crystallization solvent.
3 more elements
Dependencies are inferred from the claim text.