Antimicrobial sucralfate paste methods and compositions
OwnerPatrick D. McGrathinventor
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Abstract
Methods for the prevention and treatment of infection, preferably antibiotic resistant wound infection, using a paste formed by the reaction of sucralfate with an acid component are provided. Methods of preparing stable sucralfate compositions are disclosed. Compositions of and products containing the sucralfate paste are also described.
Claims26
A method for treating antibiotic resistant wound infections, which comprises:
- providing an antimicrobial paste which comprises reacting sucralfate with an acid component to form a reaction product that is present in an amount sufficient to at least inhibit the growth of at least one type of antibiotic resistant microorganism associated with a wound;
- and
- applying the antimicrobial paste topically to the wound to inhibit the growth of the at least one type of antibiotic resistant microorganism.
An antimicrobial sucralfate composition comprising:
- an antimicrobial paste formed from a reaction product of sucralfate with an acid component, wherein the reaction product is present in an amount sufficient to at least inhibit the growth of at least one type of antibiotic resistant microorganism;
- and
- a supernatant formed by the reaction of the sucralfate and the acid component.
An antimicrobial sucralfate composition comprising:
- an antimicrobial paste formed from a reaction product of sucralfate with an acid component, wherein the reaction product is present in an amount sufficient to at least inhibit the growth of antibiotic resistant microorganisms;
- and
- a moisturizing component to inhibit drying of the antimicrobial paste.
An antimicrobial wound dressing comprising:
- an antimicrobial paste formed from a reaction product of sucralfate incompletely reacted with an acid component;
- and
- an absorbent, flexible material that is associated with the antimicrobial paste and provides a substrate to facilitate retention of a substantial portion of the antimicrobial paste in association therewith.
A method of preparing a stable sucralfate composition comprising:
- providing a source of sucralfate;
- reacting the sucralfate with an acid component to form a stable composition comprising a paste and a supernatant, wherein the acid component reacted exceeds 8 millimoles per 5 grams of sucralfate;
- and
- modifying the supernatant to increase the pH of the supernatant to about 3 or higher.
A stable sucralfate composition comprising a reaction product of sucralfate with a sufficient amount of an acid component, wherein the molar ratio of the sucralfate to the acid component reacted is at least about 1:5 to ensure a sufficient amount of the acid component, but contains an insufficient amount of the acid component to completely dissolve the sucralfate therein.
Dependencies are inferred from the claim text.